Status of Serum Level of Vitamin D3 and Its Correlation with Serum Calcium Level in Patients Referred to Sarem Hospital in Tehrantal in Tehran

Abstract

Aims: The Investigation of vitamin D3 serum levels has been considered researched in order to assess the risk of osteoporosis in medical research. The aim of this study was to evaluate the serum level of vitamin D3 and its correlation with serum calcium level in patients referred to Sarem Hospital in Tehran. Instruments & Methods: This retrospective descriptive cross-sectional study was performed on all groups of patients (n=33377) referring to Sarem Hospital during the period of 2015-2018. Serum calcium levels were measured by cresolphthalene method and the electrochemical luminescence method was used to measure serum level of vitamin D 3 . Data were analyzed by SPSS version 24 and MedCalc version A 15.8 and Pearson's correlation test was used. Findings: The mean age of the subjects in this research was 27.56±19.43 years old. The concentrations mean of blood calcium and 25-hydroxy vitamin D 3 in the whole population was 9.80±0.60 mg/dl and 24.67±16.94 ng/ml respectively. The amount of vitamin D 3 in the subjects under 16 years was 37.56±20.30 ng/ml. An inverse and negative correlation between age with vitamin D 3 amounts (r=-0.459; P=0.0001) and a positive correlation between age and amount of calcium (r=0.124; P=0.0001) was observed. There was a correlation of significant positive, but weak between the amounts of vitamin D 3 and calcium (r=0.203; P=0.0001). Also, it was shown that the prevalence of hypovitaminosis D 3 was 40.35% in people under 16 years. The distribution of calcium and vitamin D 3 data in the statistical population was according to the non-normal distribution pattern. Conclusion: The prevalence of hypovitaminosis D 3 is high in Iran. In total, there was a weak correlation between serum calcium and vitamin D 3 levels. Calcium-Phosphate Metabolism in the Groups of Patients with Multiple Sclerosis Selected due to the Serum Level of Vitamin D3.