Recent developments in stimuli-responsive hydrogels for biomedical applications

IF 1.6 Q4 ENGINEERING, BIOMEDICAL Biosurface and Biotribology Pub Date : 2022-10-13 DOI:10.1049/bsb2.12050
Shuyun Liu, Xiaozhuang Li, Lu Han
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Abstract

Hydrogels exhibit a performance similar to that of the extracellular matrix and are compatible with human tissues and organs. Stimuli-responsive hydrogels that can respond smartly to a variety of stimuli have recently attracted extensive interest for biomedical applications. The response of these hydrogels to various single/multiple stimuli shows great potential for drug delivery, biosensors, wound dressing, cancer therapy, and tissue engineering. This review summarises the recent advances in the design of different stimuli-responsive hydrogels and their biomedical applications. We herein describe the mechanisms underlying the stimulus–response, and summarise the strategies for fabricating stimuli-responsive hydrogels that can respond to single or multiple stimuli from endogenous (i.e. pH, enzymes, glucose, and reactive oxygen species) or exogenous (i.e. magnetic and electric fields, temperature, and photo) sources. The current challenges faced by stimuli-responsive hydrogels are discussed and an outlook on future research directions is provided.

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生物医学应用刺激反应水凝胶的最新进展
水凝胶表现出类似于细胞外基质的性能,并且与人体组织和器官相容。刺激反应水凝胶可以对各种刺激做出灵敏的反应,最近引起了生物医学应用的广泛兴趣。这些水凝胶对各种单一/多重刺激的反应在药物输送、生物传感器、伤口敷料、癌症治疗和组织工程方面显示出巨大的潜力。本文综述了不同刺激反应水凝胶的设计及其生物医学应用的最新进展。我们在此描述了刺激反应的机制,并总结了制造刺激反应水凝胶的策略,这种水凝胶可以对来自内源性(即pH、酶、葡萄糖和活性氧)或外源性(即磁场、电场、温度和光)的单一或多种刺激做出反应。讨论了当前刺激响应型水凝胶面临的挑战,并对未来的研究方向进行了展望。
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来源期刊
Biosurface and Biotribology
Biosurface and Biotribology Engineering-Mechanical Engineering
CiteScore
1.70
自引率
0.00%
发文量
27
审稿时长
11 weeks
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