A short appraisal of nanodiamonds in drug delivery and targeting: recent advancements

IF 4.1 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Frontiers in Nanotechnology Pub Date : 2023-08-30 DOI:10.3389/fnano.2023.1259648
Dilpreet Singh, Supriya Ray
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Abstract

Nanodiamonds have emerged as a powerful tool in the field of drug delivery, offering exciting recent advancements and promising future prospects. Recent research has focused on enhancing drug loading efficiency, targeted delivery, and precision medicine using nanodiamonds. Strategies such as surface functionalization, polymer coatings, and encapsulation techniques have been optimized to improve drug loading, stability, and controlled release. Nanodiamonds have shown potential in targeted drug delivery through the incorporation of targeting ligands, enabling site-specific drug delivery and improved therapeutic outcomes. Additionally, nanodiamonds allow for combination therapy by carrying multiple drugs simultaneously, opening avenues for synergistic treatments. Stimuli-responsive nanodiamonds have been developed for precise and controlled drug release. Overcoming biological barriers, such as the blood-brain barrier, has been investigated by modifying nanodiamonds’ surfaces. Recent studies have highlighted innovative strategies for loading a variety of therapeutic cargoes onto nanodiamond platforms, including small molecules, proteins, nucleic acids, and even gene-editing tools. Future prospects include the integration of nanodiamonds with emerging technologies and addressing biocompatibility and safety concerns. Despite the need for further research and clinical studies, the recent advancements and future prospects of nanodiamonds in drug delivery suggest their potential to revolutionize the field and enhance patient care.
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纳米金刚石在给药和靶向方面的研究进展
纳米金刚石已成为药物递送领域的一种强大工具,提供了令人兴奋的最新进展和充满希望的未来前景。最近的研究集中在提高药物装载效率、靶向递送和使用纳米金刚石的精准医疗。表面功能化、聚合物涂层和包封技术等策略已得到优化,以提高药物负载、稳定性和控释性。纳米金刚石通过结合靶向配体在靶向药物递送方面显示出潜力,实现了位点特异性药物递送并改善了治疗效果。此外,纳米金刚石可以通过同时携带多种药物进行联合治疗,为协同治疗开辟了途径。刺激反应纳米金刚石已被开发用于精确和可控的药物释放。通过修饰纳米金刚石的表面,已经研究了克服生物屏障,如血脑屏障。最近的研究强调了将各种治疗货物装载到纳米金刚石平台上的创新策略,包括小分子、蛋白质、核酸,甚至基因编辑工具。未来的前景包括将纳米金刚石与新兴技术相结合,并解决生物相容性和安全问题。尽管需要进一步的研究和临床研究,但纳米金刚石在药物递送方面的最新进展和未来前景表明,它们有可能彻底改变该领域并加强患者护理。
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来源期刊
Frontiers in Nanotechnology
Frontiers in Nanotechnology Engineering-Electrical and Electronic Engineering
CiteScore
7.10
自引率
0.00%
发文量
96
审稿时长
13 weeks
期刊最新文献
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