Synthesis and antimicrobial activity of some quinoxaline derivatives

IF 2.4 Q3 CHEMISTRY, MULTIDISCIPLINARY Moroccan Journal of Chemistry Pub Date : 2021-05-01 DOI:10.48317/IMIST.PRSM/MORJCHEM-V9I2.25855
A. Janati, Y. Ouzidan, Y. Rodi, F. O. Chahdi, M. Chraibi, K. F. Benbrahim, I. Alaoui, A. E. Hakmaoui, M. Safi, M. Akssira, E. Essassi
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引用次数: 4

Abstract

Some new structural motifs containing the quinoxaline nucleus have been synthesized and examined for their pharmacological properties. In this study, 6-chloroquinoxaline-2,3(1H, 4H)-dione and 6 nitroquinoxaline-2,3(1H, 4H)-dione were synthesized as basic nuclei for the preparation of the new quinoxaline-2,3-diones by alkylation reactions under the conditions of phase transfer catalysis. The products were characterized by spectroscopic methods 1 H and 13 C NMR. Then, the synthesized products were tested for their antibacterial effects against two bacterial strains. The values of minimum inhibitory concentrations (MIC) vary according to the nature of the alkyl bonded to the quinoxaline nucleus.
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喹诺啉类衍生物的合成及抗菌活性研究
合成了一些含有喹喔啉核的新结构基序,并对其药理学性质进行了研究。在相转移催化条件下,合成了6-氯喹喔啉-2,3(1H,4H)-二酮和6-硝基喹喔啉-2,3(1H、4H)二酮作为碱性核,通过烷基化反应制备了新的喹喔啉2,3-二酮。通过1H和13CNMR光谱方法对产物进行了表征。然后,测试了合成产物对两种菌株的抗菌效果。最小抑制浓度(MIC)的值根据与喹喔啉核结合的烷基的性质而变化。
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来源期刊
Moroccan Journal of Chemistry
Moroccan Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
3.40
自引率
9.10%
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0
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