Benefit versus risk associated with the use of brominated flame retardants

IF 3.6 Q1 TOXICOLOGY Current Opinion in Toxicology Pub Date : 2020-08-01 DOI:10.1016/j.cotox.2020.05.003
Sam Kacew , Matthew S. Blais , A.Wallace Hayes , Wiebke Droege , Thomas G. Osimitz
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引用次数: 1

Abstract

Flame retardants are widely used in electronic equipment, construction materials, and furniture to prevent fires from starting and to slow progression. Environmental monitoring studies show their presence in house dust, biomonitoring studies occasionally detect the chemicals in biological samples, and animal toxicology studies show high-dose effects. Yet laboratory studies and real-world fire statistics confirm that flame retardants have benefits that need to be weighed against possible risks to human health. Tetrabromobisphenol A (TBBPA), is used to make brominated epoxy printed wiring boards, and to a lesser extent, flame retarded acrylonitrile butadiene styrene (ABS) plastic is often used to make electronic casings. Evaluating available toxicology data and using conservative exposure assumptions, the risks of using TBBPA in these applications is exceedingly low. Given the benefits of TBBPA and flame retardants, it is essential that carefully conducted, chemical- and use-specific risk assessment be used to inform regulatory action which could possibly undermine public fire protection.

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使用溴化阻燃剂的益处与风险
阻燃剂广泛用于电子设备、建筑材料和家具,以防止火灾的发生和减缓火势的发展。环境监测研究表明它们存在于室内灰尘中,生物监测研究偶尔会在生物样本中检测到这些化学物质,动物毒理学研究显示出高剂量效应。然而,实验室研究和真实世界的火灾统计数据证实,阻燃剂的好处需要与可能对人类健康造成的风险进行权衡。四溴双酚A (TBBPA)用于制造溴化环氧印刷线路板,在较小程度上,阻燃丙烯腈-丁二烯-苯乙烯(ABS)塑料通常用于制造电子外壳。评估现有的毒理学数据并使用保守的暴露假设,在这些应用中使用TBBPA的风险非常低。鉴于TBBPA和阻燃剂的好处,必须仔细进行化学品和特定用途的风险评估,以告知可能破坏公共消防的监管行动。
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来源期刊
Current Opinion in Toxicology
Current Opinion in Toxicology Pharmacology, Toxicology and Pharmaceutics-Toxicology
CiteScore
10.40
自引率
0.00%
发文量
43
期刊介绍: The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.
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