Synthesis of novel 1,2,3-triazolic compounds derived from natural product, by the copper(I)-catalyzed alkyne-azide (CuAAC) cycloaddition

IF 2.4 Q3 CHEMISTRY, MULTIDISCIPLINARY Moroccan Journal of Chemistry Pub Date : 2020-06-03 DOI:10.48317/IMIST.PRSM/MORJCHEM-V8I3.20510
E. Hadrami, F. E. Aroussi, I. Fichtali, A. Farah, A. Bentama
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引用次数: 2

Abstract

A series of novel 1,2,3-triazolic compounds derived from natural products (thymol, carvacrol and eugenol) was synthesized by the copper(I)-catalyzed alkyne-azide (CuAAC) cycloaddition between the corresponding propargyl ethers of each natural product and a variety of azides. The reaction conducted with catalytic amount of copper (II) sulfate and sodium ascorbate affording desired products in good yields and their structures were confirmed by spectral techniques such as 1 H NMR, 13 C NMR and high resolution mass spectrometry ( HRMS).
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用铜(I)催化的炔叠氮(CuAAC)环加成法从天然产物中合成新的1,2,3-三唑类化合物
以天然产物(百里香酚、香芹酚和丁香酚)为原料,通过铜(I)催化的炔烃叠氮化物(CuAAC)在每种天然产物的丙炔醚和各种叠氮化物之间的环加成,合成了一系列新的1,2,3-三唑类化合物。用催化量的硫酸铜(II)和抗坏血酸钠进行的反应以良好的产率提供所需产物,并且它们的结构通过光谱技术如1H NMR、13C NMR和高分辨率质谱(HRMS)得到证实。
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来源期刊
Moroccan Journal of Chemistry
Moroccan Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
3.40
自引率
9.10%
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0
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