nticoagulative Effect of Two Species of Brown Algae; Sargassum Angustifolium and Cystoseira Indica

Research in Molecular Medicine Pub Date : 2020-08-10 DOI:10.32598/RMM.8.3.1099.3

N. Obeidi, M. Mousavi, Arghavan Hosseinpouri, Hamideh Malekhayati, E. Ehsandoost

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引用次数: 1

Abstract

Background: Fucoidans are a group of sulfated fucose-rich polysaccharides that are isolated from brown marine algae and echinoderms, and recently have been found in seagrasses. Fucoidans, as well as their derivatives, have several beneficial biological effects and therapeutic potentials. In the present study, we aimed to evaluate the anticoagulative effects of two species of brown algae, namely Sargassum angustifolium (S. angustifolium) and Cystoseira indica (C. indica). Methods: Fucoidan C and fucoidan S were extracted by an ethanol/water solvent system from S. angustifolium and C. indicia, respectively. The anticoagulative effects of fucoidan C and fucoidan S were tested on 10 normal serum samples by evaluating the rate of thrombin time (PT) and prothrombin time (PTT). Results: Both fucoidan C and fucoidan S significantly increased PTT. However, no significant difference was observed in PT. Fucoidan C had a greater effect on PTT prolongation compared with fucoidan S. Conclusion: Both fucoidans extracted from S. angustifolium and C. indicia can be used as anticoagulants in biotechnology and human disorders.

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两种褐藻的抗凝血作用马尾藻和印度囊藻

背景:岩藻多糖是从褐藻和棘皮动物中分离出来的一类富含硫酸化焦糖的多糖，最近在海草中发现。岩藻胶及其衍生物具有多种有益的生物学效应和治疗潜力。本研究旨在评价两种褐藻(Sargassum angustifolium, S. angustifolium)和Cystoseira indica (C. indica)的抗凝血作用。方法:采用乙醇/水溶剂体系分别从褐藻多糖C和褐藻多糖S中提取褐藻多糖。通过测定凝血酶时间(PT)和凝血酶原时间(PTT)，观察岩藻糖聚糖C和岩藻糖聚糖S对10例正常人血清的抗凝作用。结果:褐藻聚糖C和褐藻聚糖S均能显著提高PTT。褐藻糖聚糖C与褐藻糖聚糖s相比，对PTT的延长作用更大。结论:两种褐藻糖聚糖均可作为生物技术和人类疾病的抗凝剂。

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Research in Molecular Medicine

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21 weeks