Measles seroprevalence in Thailand: are adolescents and young adults at risk of measles?

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-06-01 Epub Date: 2022-06-02 DOI:10.11622/smedj.2022058

Panit Takkinsatian, Kamolmart Wannaphahoon, Prasit Upapan, Sansnee Senawong, Olarn Prommalikit

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Abstract

Introduction: During the last decade, measles has become an important re-emerging disease in Thailand. The objective of this study was to measure measles seroprevalence and its influencing factors so as to plan an improved vaccination programme.

Methods: A total of 600 participants aged between 9 months and 50 years were divided into seven groups representing birth cohorts that experienced different measles vaccination policies. Participants' blood samples were obtained to measure measles immunoglobulin G (IgG) levels.

Results: None of the participants in the age group of 9 months had measles IgG levels beyond a protective level. Participants in the age groups 2.5, 5-15, 16-29, 30-33, 34-40 and 41-50 years had 82% (95% confidence interval [CI] 73.3-90.7), 50% (95% CI 36.1-63.9), 52% (95% CI 42.3-62.7), 70% (95% CI 61.1-78.9), 88.8% (95% CI 84.1-93.5) and 98.8% (95% CI 96.4-100.0) measles seropositivity, respectively. The study did not find any significant factors affecting measles seropositivity.

Conclusion: Individuals aged 15-34 years are vulnerable to measles infections. Supplementary vaccination should be encouraged in special situations, including postexposure prophylaxis for young adults during an outbreak and for high-risk occupations such as healthcare personnel.

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泰国麻疹血清患病率:青少年和青壮年是否存在麻疹风险?

引言在过去的十年里，麻疹已成为泰国一种重要的复发疾病。本研究的目的是测量麻疹血清流行率及其影响因素，并计划改进疫苗接种计划。方法将600名年龄在9个月至50岁之间的参与者分为7组，代表经历过不同麻疹疫苗接种政策的出生队列。采集参与者的血液样本以测量麻疹免疫球蛋白G（IgG）水平。结果9个月年龄组的参与者中没有一人的麻疹IgG水平超过保护水平。以下年龄组的参与者：2½岁、5-15岁、16-29岁、30-33岁、34-40岁和41-50岁的麻疹血清阳性率分别为82%（95%置信区间[CI]73.3-90.7）、50%（95%可信区间36.1-63.9）、52%（95%可信可信区间42.3-62.7）、70%（95%信区间61.1-78.9）、88.8%（95%可信范围84.1-93.5）和98.8%（95%置信范围96.4-100.0）。该研究没有发现任何影响麻疹血清阳性的重要因素。结论15～34岁人群易感染麻疹。应鼓励在特殊情况下进行补充疫苗接种，包括在年轻人中爆发疫情期间进行暴露后预防，或为医护人员等高风险职业提供疫苗。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.