Clinical significance of anti-nucleocapsid-IgG sero-positivity in SARS-CoV-2 infection in hospitalized patients in North Dakota

Abstract

This paper presents a case study concerning several epidemiologic-clinical parameters when they are taken hospitalized with severe COVID-19 illness. The authors provide statistical analysis of a certain group of patients tested for COVID-19 who were admitted to a hospital in North Dakota. The authors conclude that the admission rate to the ICU and the use of BiPAP, HFNC and VENT support were not significantly distinct across IgG status. However, an important parameter related to monitoring the patients’ condition - the length of stay - when assessed by IgG status was found to be significant. In overall, the paper is well-written and flows logically. Technically, the authors apply regression models to better fit their data, hence improving the quality of the results and their analysis. Although the discussion and data analysis have been performed adequately, I believe that a correlation study involving the examined variables would bring interesting insights and a richer discussion of the results.