Expression of cysteine-rich protein 61 protein in prostate carcinoma and their clinical significance

中华实验外科杂志 Pub Date : 2019-12-08 DOI:10.3760/CMA.J.ISSN.1001-9030.2019.12.004

Xu Hailiang, Gu Chaohui

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Abstract

Objective To investigate the expression and clinical significance of Cysteine-rich protein 61 (Cyr61) protein in prostate cancer. Methods We selected 68 cases of the prostate cancer tissues and 60 cases of benign prostatic hyperplasia tissues in our hospital. Immunohistochemistry was used to detect the expression of Cyr61 protein in prostate cancer tissues and benign prostatic hyperplasia tissues, and then the difference of expression between the two groups and its relationship with pathological parameters of prostate cancer were analyzed. Results The expression of Cyr61 protein in prostate cancer tissues was significantly higher than that in benign prostatic hyperplasia tissues (85.3% vs. 8.3%, χ2=75.536, P 0.05), TNM staging (χ2=0.342, P>0.05), regional lymph node metastasis (χ2=0.176, P>0.05) and distant metastasis (χ2=0.673, P>0.05), but was significantly correlated with preoperative total prostate specific antigen (tPSA) level (χ2=8.492, P<0.05), differentiation degree (χ2=13.028, P<0.05) and Gleason scores (χ2=4.032, P<0.05). Conclusion The expression of Cyr61 protein in prostate cancer tissues were significantly up-regulated, which helps to assess the progress of prostate cancer. Key words: Cysteine-rich protein 61 protein; Prostate carcinoma; Expression

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富含半胱氨酸的蛋白61在前列腺癌中的表达及其临床意义

目的探讨富含半胱氨酸蛋白61（Cyr61）蛋白在前列腺癌症中的表达及其临床意义。方法选择我院收治的68例前列腺癌症组织和60例前列腺增生组织。应用免疫组织化学方法检测Cyr61蛋白在前列腺癌症组织和前列腺增生组织中的表达，分析两组表达的差异及其与癌症病理参数的关系。结果Cyr61蛋白在前列腺癌症组织中的表达显著高于良性前列腺增生组织（85.3%vs.8.3%，X~2=75.536，P＜0.05）、TNM分期（X~2=0.342，P＞0.05）、区域淋巴结转移（X~2=1.176，P＞0.01）和远处转移（X=2=0.673，P＜0.01），但与术前总前列腺特异性抗原（tPSA）水平、分化程度、Gleason评分均显著相关。关键词：半胱氨酸富集蛋白61蛋白；前列腺癌；表达式

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中华实验外科杂志

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