Biomarker-based diagnosis of cognitive disorders in a case series

E. Kapaki, V. Constantinides, Efstratios-Stylianos Pyrgelis, P. Paraskevas, J. Papatriantafyllou, G. Paraskevas
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引用次数: 2

Abstract

The classical cerebrospinal fluid biomarkers of Alzheimer’s Disease (namely total tau, phospho-tau and amyloid beta peptide) have received much attention, since they can detect the biochemical fingerprint of Alzheimer’s disease and serve as a diagnostic aid for correct diagnosis of cognitive disorders during life. In this case series, we present 6 examples of patients with cognitive impairment of various types and severities and how biomarker data were helpful in every day diagnostic approach, combined with clinical, neuropsychological and imaging data and based on the most recent guidelines and recommendations.
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基于生物标志物的认知障碍病例系列诊断
阿尔茨海默病的经典脑脊液生物标志物(即总tau、磷酸化tau和淀粉样蛋白β肽)受到了广泛关注,因为它们可以检测阿尔茨海默病的生化指纹,并作为正确诊断生活中认知障碍的诊断辅助手段。在本系列病例中,我们介绍了6例不同类型和严重程度的认知障碍患者,以及生物标志物数据如何有助于日常诊断方法,结合临床、神经心理学和影像学数据,并基于最新的指南和建议。
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