The Acoustic Technology for Ctcs Isolation in Blood: Low-Cost Devices

Abstract

The use of blood samples as liquid biopsy for cancer diagnosis offers benefits over traditional tissue biopsy. Tumor cells are shed from primary distant sites in the bloodstream to circulate, becoming biomarkers of interest for cancer prognostics, monitoring treatment response in personalized medicine and contain information about possible specific mutations of a tumor Thus, isolation of viable circulating tumor cells (CTCs) is essential for liquid biopsy, which has shown to be an efficient alternative to tissue biopsy [1]. Chemotherapy and other therapy treatments, as well as mechanisms of treatment resistance can be monitored through the analysis of CTCs. However, isolation of CTCs from blood is nontrivial due to their extreme rarity in comparison to the blood cells [2].