Bioconjugated Plasmonic Nanoparticles for Enhanced Skin Penetration

IF 7.1 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Topics in Current Chemistry Pub Date : 2019-12-16 DOI:10.1007/s41061-019-0273-0
David Alba-Molina, Juan J. Giner-Casares, Manuel Cano
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引用次数: 12

Abstract

Plasmonic nanoparticles (NPs) are one of the most promising and studied inorganic nanomaterials for different biomedical applications. Plasmonic NPs have excellent biocompatibility, long-term stability against physical and chemical degradation, relevant optical properties, well-known synthesis methods and tuneable surface functionalities. Herein, we?review recently reported bioconjugated plasmonic NPs using different chemical approaches and loading cargoes (such as drugs, genes, and proteins) for enhancement of transdermal delivery across biological tissues. The main aim is to understand the interaction of the complex skin structure with biomimetic plasmonic NPs. This knowledge is not only important in enhancing transdermal delivery of pharmaceutical formulations but also for controlling undesired skin penetration of industrial products, such as cosmetics, sunscreen formulations and any other mass-usage consumable that contains plasmonic?NPs.

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增强皮肤穿透性的生物共轭等离子体纳米颗粒
等离子体纳米粒子(NPs)是生物医学领域研究最广泛的无机纳米材料之一。等离子体NPs具有优异的生物相容性、抗物理和化学降解的长期稳定性、相关的光学性质、已知的合成方法和可调的表面功能。在此,我们呢?最近报道了生物共轭等离子体NPs使用不同的化学方法和装载货物(如药物、基因和蛋白质)来增强跨生物组织的透皮递送。主要目的是了解复杂皮肤结构与仿生等离子体NPs的相互作用。这一知识不仅对加强药物配方的透皮递送很重要,而且对控制工业产品(如化妆品、防晒霜配方和任何其他含有等离子体NPs的大量使用消费品)的不希望的皮肤渗透也很重要。
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来源期刊
Topics in Current Chemistry
Topics in Current Chemistry Chemistry-General Chemistry
CiteScore
13.70
自引率
1.20%
发文量
48
期刊介绍: Topics in Current Chemistry is a journal that presents critical reviews of present and future trends in modern chemical research. It covers all areas of chemical science, including interactions with related disciplines like biology, medicine, physics, and materials science. The articles in this journal are organized into thematic collections, offering a comprehensive perspective on emerging research to non-specialist readers in academia or industry. Each review article focuses on one aspect of the topic and provides a critical survey, placing it in the context of the collection. Selected examples highlight significant developments from the past 5 to 10 years. Instead of providing an exhaustive summary or extensive data, the articles concentrate on methodological thinking. This approach allows non-specialist readers to understand the information fully and presents the potential prospects for future developments.
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