Altered amino acid profiles of the “mother–fetus” system in COVID-19

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Bulletin of Russian State Medical University Pub Date : 2022-05-01 DOI:10.24075/brsmu.2022.025

N. Lomova, V. Chagovets, E. Dolgopolova, A. Novoselova, Uliana Petrova, R. Shmakov, V. Frankevich

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引用次数: 1

Abstract

Systemic nature of the human body response to SARS-CoV-2 requires dedicated analysis at the molecular level. COVID-19 during pregnancy affects maternal health and may entail complications in the early neonatal period and possibly long-term consequences for the offspring. The aim of the study was to assess the impact of COVID-19 on amino acid profiles in maternal venous blood, amniotic fluid and umbilical cord blood in order to develop a diagnostic panel accounting for possible consequences. The main group included 29 pregnant patients with a confirmed diagnosis of COVID-19 and the control group included 17 somatically healthy pregnant women. Amino acid profiles of the biological fluids were measured by high-performance liquid chromatography combined to mass spectrometry (HPLC-MS) and assessed in logistic regression models. The analysis revealed altered content of certain amino acids, their biosynthetic precursors and metabolites in the biological fluids collected from patients with COVID-19 possibly reflecting the development of systemic inflammatory reaction and associated changes in gene expression profiles. These findings may guide further research into health outcomes for neonates born from mothers infected with SARS-CoV-2 during pregnancy. The study may help to develop advanced recommendations and differential care protocols for pregnant women and newborns diagnosed with COVID-19.

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新冠肺炎中“母婴”系统氨基酸谱的改变

人体对严重急性呼吸系统综合征冠状病毒2型反应的系统性需要在分子水平上进行专门分析。怀孕期间的新冠肺炎会影响产妇健康，并可能导致新生儿早期并发症，并可能对后代产生长期影响。该研究的目的是评估新冠肺炎对母体静脉血、羊水和脐带血中氨基酸谱的影响，以开发一个诊断小组来解释可能的后果。主要组包括29名确诊为新冠肺炎的孕妇，对照组包括17名身体健康的孕妇。通过高效液相色谱-质谱联用（HPLC-MS）测量生物流体的氨基酸图谱，并在逻辑回归模型中进行评估。分析显示，从新冠肺炎患者收集的生物液中，某些氨基酸、其生物合成前体和代谢产物的含量发生了变化，这可能反映了全身炎症反应的发展和基因表达谱的相关变化。这些发现可能会指导对妊娠期间感染严重急性呼吸系统综合征冠状病毒2型的母亲所生新生儿的健康结果的进一步研究。该研究可能有助于为诊断为新冠肺炎的孕妇和新生儿制定先进的建议和差异化护理方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Russian State Medical University MEDICINE, GENERAL & INTERNAL-

CiteScore

0.80

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0.00%

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期刊介绍： Bulletin of Russian State Medical University (Bulletin of RSMU, ISSN Print 2500–1094, ISSN Online 2542–1204) is a peer-reviewed medical journal of Pirogov Russian National Research Medical University (Moscow, Russia). The original language of the journal is Russian (Vestnik Rossiyskogo Gosudarstvennogo Meditsinskogo Universiteta, Vestnik RGMU, ISSN Print 2070–7320, ISSN Online 2070–7339). Founded in 1994, it is issued once every two months publishing articles on clinical medicine and medical and biological sciences, first of all oncology, neurobiology, allergy and immunology, medical genetics, medical microbiology and infectious diseases. Every issue is thematic. Deadlines for manuscript submission are announced in advance. The number of publications on topics in spite of the issue topic is limited. The journal accepts only original articles submitted by their authors, including articles that present methods and techniques, clinical cases and opinions. Authors must guarantee that their work has not been previously published elsewhere in whole or in part and in other languages and is not under consideration by another scientific journal. The journal publishes only one review per issue; the review is ordered by the editors.