Clarissa Tania, Edwin Raja Pardamean Lumban Tobing, Christiano Tansol, Patricia Diana Prasetiyo, Caesar Khairul Wallad, Timotius Ivan Hariyanto
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引用次数: 1
Abstract
Objective: Vitamin D has been hypothesized to have a potential role in altering sperm motility and metabolism. However, experimental studies have demonstrated inconsistent results between vitamin D and sperm parameters. This study aims to investigate the role of vitamin D supplementation to improve sperm parameters in infertile men.
Methods: This is a systematic review and meta-analysis study. We comprehensively conducted a search on ClinicalTrials.gov, IRCT.ir, Europe PMC, and PubMed and collected published studies on vitamin D supplementation and sperm parameters for infertile men. The risk of bias was assessed by using Risk of Bias version 2 (RoB v2) and the statistical analysis was performed by using Review Manager 5.4 software.
Results: Five trials with a total of 648 infertile men were included. Our meta-analysis showed that supplementation with vitamin D may significantly improve total sperm motility [mean difference 4.96 (95% CI 0.38, 9.54), p = 0.03, I2 = 69%], progressive sperm motility [mean difference 4.14 (95% CI 0.25, 8.02), p = 0.04, I2 = 89%], and normal sperm morphology [mean difference 0.44 (95% CI 0.30, 0.57), p < 0.00001, I2 = 0%] better than placebo in infertile men. However, total sperm count (p = 0.15), sperm concentration (p = 0.82), and semen volume (p = 0.83) did not differ significantly between two groups.
Conclusions: Vitamin D supplementation may improve sperm motility, progressive sperm motility, and morphology in infertile men. Vitamin D supplementation may be considered in managing male fertility issue.
研究目的维生素 D 被认为在改变精子活力和新陈代谢方面具有潜在作用。然而，实验研究表明维生素 D 与精子参数之间的关系并不一致。本研究旨在探讨补充维生素 D 对改善不育男性精子参数的作用：这是一项系统回顾和荟萃分析研究。我们在 ClinicalTrials.gov、IRCT.ir、Europe PMC 和 PubMed 上进行了全面检索，收集了已发表的有关不育男性补充维生素 D 和精子参数的研究。使用Risk of Bias version 2（RoB v2）评估偏倚风险，并使用Review Manager 5.4软件进行统计分析：结果：共纳入了五项试验，涉及 648 名不育男性。我们的荟萃分析表明，与安慰剂相比，补充维生素D可显著改善不育男性的总精子活力[平均差异为4.96（95% CI 0.38，9.54），p = 0.03，I2 = 69%]、渐进性精子活力[平均差异为4.14（95% CI 0.25，8.02），p = 0.04，I2 = 89%]和正常精子形态[平均差异为0.44（95% CI 0.30，0.57），p I2 = 0%]。然而，精子总数（p = 0.15）、精子浓度（p = 0.82）和精液量（p = 0.83）在两组之间没有显著差异：结论：补充维生素 D 可改善不育男性的精子活力、渐进性精子活力和形态。在处理男性生育问题时，可考虑补充维生素 D。
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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