Myelopoiesis, metabolism and therapy: a crucial crossroads in cancer progression

IF 4.1 Q2 CELL BIOLOGY Cell Stress Pub Date : 2019-07-01 DOI:10.15698/cst2019.09.197
A. Sica, V. Guarneri, A. Gennari
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引用次数: 32

Abstract

Cancers promote immunological stresses that induce alterations of the myelopoietic output, defined as emergency myelopoiesis, which lead to the generation of different myeloid populations endowed with tumor-promoting activities. New evidence indicates that acquisition of this tumor-promoting phenotype by myeloid cells is the result of a multistep process, encompassing initial events originating into the bone marrow and later steps operating in the tumor microenvironment. The careful characterization of these sequential mechanisms is likely to offer new potential therapeutic opportunities. Here, we describe relevant mechanisms of myeloid cells reprogramming that instate immune dysfunctions and limit effective responses to anticancer therapy and discuss the influence that metabolic events, as well as chemotherapy, elicit on such events.
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骨髓生成、代谢和治疗:癌症进展的关键十字路口
癌症促进免疫应激,诱导骨髓输出的改变,定义为紧急骨髓生成,导致产生具有促肿瘤活性的不同骨髓群。新的证据表明,骨髓细胞获得这种促肿瘤表型是一个多步骤过程的结果,包括起源于骨髓的初始事件和在肿瘤微环境中操作的后续步骤。这些顺序机制的仔细表征可能提供新的潜在治疗机会。在这里,我们描述了骨髓细胞重编程的相关机制,这些机制导致免疫功能障碍,限制对抗癌治疗的有效反应,并讨论了代谢事件和化疗对这些事件的影响。
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来源期刊
Cell Stress
Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)
CiteScore
13.50
自引率
0.00%
发文量
21
审稿时长
15 weeks
期刊介绍: Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.
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