{"title":"Quorum sensing in synthetic biology: A review","authors":"Alice Boo , Rodrigo Ledesma Amaro , Guy-Bart Stan","doi":"10.1016/j.coisb.2021.100378","DOIUrl":null,"url":null,"abstract":"<div><p><span>In nature, quorum sensing is one of the mechanisms bacterial populations use to communicate with their own species or across species to coordinate behaviours. For the last 20 years, synthetic biologists have recognised the remarkable properties of quorum sensing to build </span>genetic<span> circuits responsive to population density. This has led to progress in designing dynamic, coordinated and sometimes multicellular systems for bioproduction in metabolic engineering and for increased spatial and temporal complexity in synthetic biology. In this review, we highlight recent works focused on using quorum sensing to engineer cell–cell behaviour.</span></p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"28 ","pages":"Article 100378"},"PeriodicalIF":3.4000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.coisb.2021.100378","citationCount":"26","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Systems Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S245231002100072X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 26
Abstract
In nature, quorum sensing is one of the mechanisms bacterial populations use to communicate with their own species or across species to coordinate behaviours. For the last 20 years, synthetic biologists have recognised the remarkable properties of quorum sensing to build genetic circuits responsive to population density. This has led to progress in designing dynamic, coordinated and sometimes multicellular systems for bioproduction in metabolic engineering and for increased spatial and temporal complexity in synthetic biology. In this review, we highlight recent works focused on using quorum sensing to engineer cell–cell behaviour.
期刊介绍：
Current Opinion in Systems Biology is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of Systems Biology. It publishes polished, concise and timely systematic reviews and opinion articles. In addition to describing recent trends, the authors are encouraged to give their subjective opinion on the topics discussed. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following areas will be covered by Current Opinion in Systems Biology: -Genomics and Epigenomics -Gene Regulation -Metabolic Networks -Cancer and Systemic Diseases -Mathematical Modelling -Big Data Acquisition and Analysis -Systems Pharmacology and Physiology -Synthetic Biology -Stem Cells, Development, and Differentiation -Systems Biology of Mold Organisms -Systems Immunology and Host-Pathogen Interaction -Systems Ecology and Evolution
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