Ahmed Darwish, O. Elyashiv, Radha Graham, Rowan E Miller
{"title":"Recent trends in molecular testing and maintenance targeted therapies in ovarian cancer","authors":"Ahmed Darwish, O. Elyashiv, Radha Graham, Rowan E Miller","doi":"10.1111/tog.12880","DOIUrl":null,"url":null,"abstract":"Surgical cytoreduction and platinum‐based chemotherapy are the mainstays of ovarian cancer treatment, but 70% of patients with advanced‐stage disease will relapse after responding to first‐line chemotherapy. Recent randomised controlled trials have shown significant improvement in progression‐free survival by adding maintenance therapy including either PARP inhibitors (PARPi), bevacizumab (VEGF‐A inhibitor), or both. Homologous recombination repair is a pathway to repair DNA breaks; homologous recombination deficiency (HRD) is encountered in approximately 50% of ovarian high‐grade serous cancers (HGSC). Patients with HRD tumours demonstrate better progression‐free survival outcomes with PARPi. HRD testing is now approved for patients with high‐grade ovarian cancers including HGSC.","PeriodicalId":51862,"journal":{"name":"Obstetrician & Gynaecologist","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obstetrician & Gynaecologist","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/tog.12880","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Surgical cytoreduction and platinum‐based chemotherapy are the mainstays of ovarian cancer treatment, but 70% of patients with advanced‐stage disease will relapse after responding to first‐line chemotherapy. Recent randomised controlled trials have shown significant improvement in progression‐free survival by adding maintenance therapy including either PARP inhibitors (PARPi), bevacizumab (VEGF‐A inhibitor), or both. Homologous recombination repair is a pathway to repair DNA breaks; homologous recombination deficiency (HRD) is encountered in approximately 50% of ovarian high‐grade serous cancers (HGSC). Patients with HRD tumours demonstrate better progression‐free survival outcomes with PARPi. HRD testing is now approved for patients with high‐grade ovarian cancers including HGSC.
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