Male-pattern hair loss: Comprehensive identification of the associated genes as a basis for understanding pathophysiology.

IF 0.8 4区 生物学 Q4 GENETICS & HEREDITY Medizinische Genetik Pub Date : 2023-04-05 eCollection Date: 2023-04-01 DOI:10.1515/medgen-2023-2003
Sabrina K Henne, Markus M Nöthen, Stefanie Heilmann-Heimbach
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Abstract

Male-pattern hair loss (MPHL) is a highly heritable and prevalent condition that is characterized by progressive hair loss from the frontotemporal and vertex scalp. This androgen-dependent hair loss may commence during puberty, and up to 80 % of European men experience some degree of MPHL during their lifetime. Current treatment options for MPHL have limited efficacy, and improved understanding of the underlying biological causes is required to facilitate novel therapeutic approaches. To date, molecular genetic studies have identified 389 associated genomic regions, have implicated numerous genes in these regions, and suggested pathways that are likely to contribute to key pathophysiological mechanisms in MPHL. This review provides an overview of the current status of MPHL genetic research. We discuss the most significant achievements, current challenges, and anticipated developments in the field, as well as their potential to advance our understanding of hair (loss) biology, and to improve hair loss prediction and treatment.

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男性型脱发:综合鉴定相关基因作为理解病理生理学的基础
摘要男性型脱发(MPHL)是一种高度遗传和流行的疾病,其特征是额颞叶和头顶头皮进行性脱发。这种雄激素依赖性脱发可能在青春期开始,最多可达80 % 大多数欧洲男性一生中都会经历某种程度的MPHL。目前MPHL的治疗方案疗效有限,需要更好地了解潜在的生物学原因,以促进新的治疗方法。到目前为止,分子遗传学研究已经确定了389个相关的基因组区域,在这些区域中涉及许多基因,并提出了可能有助于MPHL关键病理生理机制的途径。本文综述了MPHL基因研究的现状。我们讨论了该领域最重要的成就、当前的挑战和预期的发展,以及它们在促进我们对脱发生物学的理解以及改善脱发预测和治疗方面的潜力。
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来源期刊
Medizinische Genetik
Medizinische Genetik Medicine-Genetics (clinical)
CiteScore
1.40
自引率
9.10%
发文量
48
审稿时长
>12 weeks
期刊介绍: medizinischegenetik is a scientific journal that is owned and published by the German Society of Human Genetics e.V. since 1989. The journal was founded by Prof. Jan Murken, München. Self-published until 2006, from 2007-2019 published at Springer Verlag and since 2020 at De Gruyter. medizinischegenetik serves education and training among colleagues, the interdisciplinary exchange of knowledge in all areas of human genetics in clinics, practice, research and teaching. Each issue of the quarterly journal deals with a focus that provides a comprehensive overview of current developments in specific clinical pictures, technical developments and therapeutic approaches. All reviews are written in English language. The journal thus creates a platform for the international exchange of knowledge and increased awareness of German research activities in the scientific community. In addition, medizinischegenetik contains information on activities in its own subject in the German-language section. This includes conference reports, association announcements, personnel matters, statements and guidelines. With health policy questions, historical retrospectives and comments on current developments, the profession takes a stand on human genetic issues in Germany, Austria and Switzerland.
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