Mulugeta S. Goangul, Rance Solomon, Daniel Devito, C. Brown, J. Coopper, D. Erenso, Ying Gao, Aline Pellizzaro, Jennifer M. Revalee, H. Crogman
{"title":"The Effectiveness of Suffruticosol B in Treating Lung Cancer by the Laser Trapping Technique","authors":"Mulugeta S. Goangul, Rance Solomon, Daniel Devito, C. Brown, J. Coopper, D. Erenso, Ying Gao, Aline Pellizzaro, Jennifer M. Revalee, H. Crogman","doi":"10.3390/biophysica3010008","DOIUrl":null,"url":null,"abstract":"We used laser trapping to study the effects of suffruticosol B on lung cancer cells. Physical and mechanical changes were found to be statistically significant, with a 63.97% increase over untreated cells and a 79.57% increase over untreated cells after treatment for 3 or 6 h, respectively. The treatment affected the internal structure of the cells, with changes in their elastic properties. The cellular responses showed that treatment with suffruticosol B resulted in the decreased proliferation and invasion of cancer cells. These results suggest that the treatment may be useful in preventing or treating lung cancer.","PeriodicalId":72401,"journal":{"name":"Biophysica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophysica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/biophysica3010008","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
We used laser trapping to study the effects of suffruticosol B on lung cancer cells. Physical and mechanical changes were found to be statistically significant, with a 63.97% increase over untreated cells and a 79.57% increase over untreated cells after treatment for 3 or 6 h, respectively. The treatment affected the internal structure of the cells, with changes in their elastic properties. The cellular responses showed that treatment with suffruticosol B resulted in the decreased proliferation and invasion of cancer cells. These results suggest that the treatment may be useful in preventing or treating lung cancer.
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