Biochemical Changes in the Serum of Experimental Animals Treated with Acorus calamus Rhizome

Q2 Social Sciences Studies on Ethno-Medicine Pub Date : 2017-07-03 DOI:10.1080/09735070.2017.1353109

S. Sreejaya, D. Archana, K. Santhy

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引用次数: 3

Abstract

ABSTRACT The present study was undertaken to examine the effect of Acorus calamus rhizome on serum biochemical parameters in experimental animals. Tumor was induced in mice intraperitoneally using Dalton’s ascites lymphoma cells. Methanol extract of Acorus calamus (MEAC) was administered to the mice at the dose of 100 and 200 mg/kg/day. The effect of the extract on serum enzyme levels was evaluated by analyzing the serum hematology and clinical biochemistry of experimental animals. Inoculation of Dalton’s ascites lymphoma cells caused significant decrease in the serum levels of alkaline phosphatise (ALP), serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) in the treated mice when compared with the control group. Urea, uric acid, creatinine and triglyceride levels were controlled significantly. The results clearly indicated that the rhizome extract has the ability to retain the altered biochemical parameters as normal in induced mice supporting its potent anticancer and hepatoprotective effects.

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菖蒲根茎对实验动物血清生化的影响

摘要本研究旨在探讨菖蒲根对实验动物血清生化指标的影响。采用道尔顿腹水淋巴瘤细胞腹腔诱导小鼠肿瘤。以100、200 mg/kg/d给药菖蒲甲醇提取物。通过对实验动物的血清血液学和临床生化分析，评价提取物对血清酶水平的影响。接种道尔顿腹水淋巴瘤细胞后，实验组小鼠血清碱性磷酸酶(ALP)、谷氨酸草酰乙酸转氨酶(SGOT)和谷氨酸丙酮酸转氨酶(SGPT)水平显著低于对照组。尿素、尿酸、肌酐和甘油三酯水平得到显著控制。结果表明，根茎提取物能使小鼠的生化指标保持正常，具有较强的抗癌和保肝作用。

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来源期刊

Studies on Ethno-Medicine Social Sciences-Cultural Studies

CiteScore

0.50

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0.00%

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期刊介绍： Studies on Ethno-Medicine is a peer reviewed, internationally circulated journal. It publishes reports of original research, theoretical articles, timely reviews, brief communications, book reviews and other publications in the interdisciplinary field of ethno-medicine. The journal serves as a forum for physical, social and life scientists as well as for health professionals. The transdisciplinary areas covered by this journal include, but are not limited to, Physical Sciences, Anthropology, Sociology, Geography, Life Sciences, Environmental Sciences, Botany, Agriculture, Home Science, Zoology, Genetics, Biology, Medical Sciences, Public Health, Demography and Epidemiology. The journal publishes basic, applied and methodologically oriented research from all such areas. The journal is committed to prompt review, and priority publication is given to manuscripts with novel or timely findings, and to manuscript of unusual interest. Further, the manuscripts are categorised under three types, namely - Regular articles, Short Communications and Reviews. The researchers are invited to submit original papers in English (papers published elsewhere or under consideration elsewhere shall not be considered).