The Role of High-sensitive C-Reactive Protein in predicting Severity of Coronary Artery Disease in Patients with Acute Coronary Syndromes

IF 0.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pakistan Heart Journal Pub Date : 2023-04-01 DOI:10.47144/phj.v56i1.2468
S. Kiani, Waheed Ashraf, M. Khan, A. Chaudhry, N. Azad, Waheed Ul Rehman, A. Zafar
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Abstract

Objectives: We investigated the correlation between baseline C-reactive protein (Hs-CRP) levels and severity of coronary artery disease (CAD), measured in terms of Syntax Score (SScore), among patients presenting with acute coronary syndromes (ACS). Methodology: This cross-sectional study was conducted at the Armed Forces Institute of Cardiology (AFIC), Rawalpindi, from April 2022 to October 2022. Baseline Hs-CRP levels were obtained for all the patients. Patients were divided into three groups as per the SScore as low (≤ 22), intermediate (≥ 23), and high (≥ 33) burden of CAD. Results: Out of the 200 patients studied, 82.5% (165) were males, and mean age was 60.16±10.66 years. Diabetics were 50% (100) of the sample, 48.5% (97) were hypertensive, and smokers were 17.5% (35). Median Hs-CRP was 4.0 mg/L [2.0-12.5 mg/L], and median left ventricular ejection fraction (LVEF) was 45% [40-55%]. Median SScore was 23.5 [14.5-30.0], with 44.5% (89) categorized as low, 36.5% (73) as intermediate, and 19% (38) as high burden of CAD. The correlation between Hs-CRP and SScore was 0.236 (p=0.001) and -0.229 (p=0.001) with LVEF. A significant increase in Hs-CRP was observed in relation to the burden of CAD (p<0.001) with median of 2.0 mg/L [1.0-4.2 mg/L], 6.0 mg/L [3.1-15.7 mg/L], and 12.5 mg/L [5.8-20.7 mg/L] for low, intermediate, high burden of CAD, respectively. Conclusion: Admission Hs-CRP was found to be positively correlated with the burden of CAD and negatively correlated with LVEF in patients with ACS.
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高敏C反应蛋白在预测急性冠状动脉综合征患者冠状动脉疾病严重程度中的作用
目的:研究急性冠状动脉综合征(ACS)患者的基线c反应蛋白(Hs-CRP)水平与冠状动脉疾病(CAD)严重程度(以句法评分(SScore)衡量)之间的相关性。方法:这项横断面研究于2022年4月至2022年10月在拉瓦尔品第的武装部队心脏病研究所(AFIC)进行。获得所有患者的基线Hs-CRP水平。将患者按照SScore分为低(≤22)、中(≥23)、高(≥33)三组。结果:200例患者中,82.5%(165例)为男性,平均年龄为60.16±10.66岁。糖尿病患者占50%(100人),高血压患者占48.5%(97人),吸烟者占17.5%(35人)。Hs-CRP中位数为4.0 mg/L [2.0 ~ 12.5 mg/L],左室射血分数(LVEF)中位数为45%[40 ~ 55%]。SScore中位数为23.5[14.5-30.0],其中44.5%(89人)为低负担,36.5%(73人)为中等负担,19%(38人)为高负担。Hs-CRP与SScore与LVEF的相关性分别为0.236 (p=0.001)和-0.229 (p=0.001)。Hs-CRP与冠心病负担相关(p<0.001),中位数分别为2.0 mg/L [1.0-4.2 mg/L]、6.0 mg/L [3.1-15.7 mg/L]和12.5 mg/L [5.8-20.7 mg/L]。结论:ACS患者入院Hs-CRP与冠心病负担呈正相关,与LVEF负相关。
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来源期刊
Pakistan Heart Journal
Pakistan Heart Journal CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
0.20
自引率
0.00%
发文量
64
审稿时长
6 weeks
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