Survey on Hepatitis B virus and Hepatitis C Virus Coinfection in the Human Immunodeficiency Virus-infected Patients

Q4 Immunology and Microbiology Journal of Bacteriology and Virology Pub Date : 2022-09-30 DOI:10.4167/jbv.2022.52.3.115
Hye-Yeoun Lee, So-Hyun Lee, Woon-Ho Kim, Mi-young Seo, Hak Kim, Ji-Hye Park
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Abstract

Human immunodeficiency virus (HIV), a blood-borne viral disease, weakens the immune system and causes opportunistic infections or cancers, which can eventually lead to Acquired Immune Deficiency Syndrome (AIDS). Generally antiretroviral therapy (ART) in HIV infected patients reduces morbidity and mortality, but also increases the risk of liver disease in patients coinfected with Hepatitis B virus (HBV) or Hepatitis C virus (HCV), previously known as the leading cause of death from HIV infection. In this study, HIV positive-sera were investigated seroprevalence of HBV and HCV which were requested for HIV test from 2020 to 2021. Of the total 232 samples, there are 184 cases (79.1%) in hospital, 33 cases (14.2%) in public health center, 6 cases (2.6%) in correctional institution and 2 cases (0.9%) in the military manpower administration. Hepatitis B virus surface antigen (HBsAg) was detected in 13 cases (5.6%) and hepatitis C virus antibody (anti-HCV) in 16 cases (6.9%) and also both in 4 cases (1.7%) of 232 samples. The results of HBsAg and hepatitis B virus core antibody (anti-HBc) for 107 samples were anti-HBc positive in 36 cases (35.6%) and HBsAg positive in 4 cases (1.7%). The results confirmed that coinfection with HBV and HCV was more common in HIV infected people than in the general population in Korea. These findings from this study were provided as fundamental data for HIV infection prevention and ART therapy selection.
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人类免疫缺陷病毒感染者乙型肝炎病毒和丙型肝炎病毒合并感染的调查
人类免疫缺陷病毒(HIV)是一种血液传播的病毒性疾病,它会削弱免疫系统,导致机会性感染或癌症,最终导致获得性免疫缺陷综合征(AIDS)。一般来说,艾滋病毒感染患者的抗逆转录病毒治疗(ART)降低了发病率和死亡率,但也增加了合并感染乙型肝炎病毒(HBV)或丙型肝炎病毒(HCV)的患者发生肝脏疾病的风险,这两种病毒以前被认为是艾滋病毒感染导致死亡的主要原因。本研究调查了2020 - 2021年HIV检测要求的HIV阳性血清HBV和HCV的血清阳性率。232例样本中,医院184例(79.1%),公共卫生院33例(14.2%),惩教机构6例(2.6%),军队人事管理局2例(0.9%)。232份样本中检出乙型肝炎病毒表面抗原(HBsAg) 13例(5.6%),丙型肝炎病毒抗体(anti-HCV) 16例(6.9%),两者均检出4例(1.7%)。107份样本HBsAg和乙型肝炎病毒核心抗体(抗- hbc)检测结果显示,抗- hbc阳性36例(35.6%),HBsAg阳性4例(1.7%)。结果证实,在韩国HIV感染者中HBV和HCV合并感染比一般人群更常见。本研究结果可为HIV感染预防和ART治疗选择提供基础数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Bacteriology and Virology
Journal of Bacteriology and Virology Immunology and Microbiology-Immunology
CiteScore
0.80
自引率
0.00%
发文量
16
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