{"title":"Data validation and statistical issues such as power and other considerations in genome‐wide association study (GWAS)","authors":"Makoto Tomita","doi":"10.1002/wics.1601","DOIUrl":null,"url":null,"abstract":"A series of steps in genomic data analysis will be presented. In data validation, starting with marker quality control, he mentioned structuring problems from ethnic populations, genome‐wide significant levels, Manhattan plots, and Haploview. Statistical issues such as power, sample size calculation, false discovery rate, and QQ plot of p‐values were also introduced.","PeriodicalId":47779,"journal":{"name":"Wiley Interdisciplinary Reviews-Computational Statistics","volume":" ","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2022-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Wiley Interdisciplinary Reviews-Computational Statistics","FirstCategoryId":"100","ListUrlMain":"https://doi.org/10.1002/wics.1601","RegionNum":2,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"STATISTICS & PROBABILITY","Score":null,"Total":0}
引用次数: 0
Abstract
A series of steps in genomic data analysis will be presented. In data validation, starting with marker quality control, he mentioned structuring problems from ethnic populations, genome‐wide significant levels, Manhattan plots, and Haploview. Statistical issues such as power, sample size calculation, false discovery rate, and QQ plot of p‐values were also introduced.
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