Gallium-68-Labeled Prostate-Specific Membrane Antigen (68Ga-PSMA) Uptake in Renal Cell Carcinoma and Lung Adenocarcinoma: A Case Report

IF 0.2 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Iranian Journal of Radiology Pub Date : 2021-10-31 DOI:10.5812/iranjradiol.115962

Abtin Doroudinia, P. Mehrian, Maedeh Forghani

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引用次数: 0

Abstract

: Gallium-68-labeled prostate-specific membrane antigen (68Ga-PSMA), as a relatively new positron emission tomography (PET) radiotracer, can be used to evaluate tumors other than prostate cancer, including renal cell carcinoma and probably non-small cell lung cancer, as discussed in our case. We present the case of a 65-year-old man with a history of lung adenocarcinoma diagnosed in 2015 and a subsequent diagnosis of renal cell carcinoma in 2018, treated with a right lower lobectomy and a left partial nephrectomy, respectively. Both conditions were evaluated using 18F-fluorodeoxyglucose (18F-FDG) PET/computed tomography (CT) scan before surgery. A rise in prostate-specific antigen (PSA) was detected in the follow-up in September 2020, and the patient was referred for a 68Ga-PSMA PET/CT scan following pelvic magnetic resonance imaging (MRI). The 68Ga-PSMA PET/CT scan demonstrated avid lesions in both lung and kidney surgical beds. The 68Ga-PSMA PET/CT scan can be potentially used in patients with recurrent renal cell carcinoma to detect metastasis. This modality may also detect non-small cell lung cancer lesions; however, further investigation is needed.

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镓-68标记前列腺特异性膜抗原(68Ga-PSMA)在肾细胞癌和肺腺癌中的摄取:1例报告

镓-68标记的前列腺特异性膜抗原(68Ga-PSMA)作为一种相对较新的正电子发射断层扫描(PET)放射性示踪剂，可用于评估前列腺癌以外的肿瘤，包括肾细胞癌和非小细胞肺癌，如本病例所讨论的。我们报告了一名65岁的男性病例，他于2015年诊断出肺腺癌病史，随后于2018年诊断为肾细胞癌，分别接受了右下肺叶切除术和左侧部分肾切除术。术前使用18f -氟脱氧葡萄糖(18F-FDG) PET/计算机断层扫描(CT)对两种情况进行评估。在2020年9月的随访中检测到前列腺特异性抗原(PSA)升高，并在盆腔磁共振成像(MRI)后转介患者进行68Ga-PSMA PET/CT扫描。68Ga-PSMA PET/CT扫描显示肺和肾手术床明显病变。68Ga-PSMA PET/CT扫描可用于复发性肾细胞癌患者的转移检测。这种方式也可以检测非小细胞肺癌病变;然而，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Radiology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

0.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Iranian Journal of Radiology is the official journal of Tehran University of Medical Sciences and the Iranian Society of Radiology. It is a scientific forum dedicated primarily to the topics relevant to radiology and allied sciences of the developing countries, which have been neglected or have received little attention in the Western medical literature. This journal particularly welcomes manuscripts which deal with radiology and imaging from geographic regions wherein problems regarding economic, social, ethnic and cultural parameters affecting prevalence and course of the illness are taken into consideration. The Iranian Journal of Radiology has been launched in order to interchange information in the field of radiology and other related scientific spheres. In accordance with the objective of developing the scientific ability of the radiological population and other related scientific fields, this journal publishes research articles, evidence-based review articles, and case reports focused on regional tropics. Iranian Journal of Radiology operates in agreement with the below principles in compliance with continuous quality improvement: 1-Increasing the satisfaction of the readers, authors, staff, and co-workers. 2-Improving the scientific content and appearance of the journal. 3-Advancing the scientific validity of the journal both nationally and internationally. Such basics are accomplished only by aggregative effort and reciprocity of the radiological population and related sciences, authorities, and staff of the journal.