Efficacy of Biological and Physical Enhancement on Targeted Muscle Reinnervation

IF 10.5 Q1 ENGINEERING, BIOMEDICAL Cyborg and bionic systems (Washington, D.C.) Pub Date : 2022-09-15 DOI:10.34133/2022/9759265

Siyang Zhong, Zijun Zhang, Huan Su, Chenyang Li, Yifeng Lin, Wei Lu, Zhendong Jiang, Lin Yang

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引用次数: 3

Abstract

Targeted muscle reinnervation (TMR) is a microsurgical repair technique to reconstruct the anatomical structure between the distal nerve and the muscle stump to provide more myoelectric information to the artificially intelligent prosthesis. Postoperative functional electrical stimulation treatment of the patient's denervated muscle or proximal nerve stump as well as nerve growth factor injection is effective in promoting nerve regeneration and muscle function recovery. In this experiment, we successfully established a TMR rat model and divided Sprague-Dawley (SD) adult male rats into TMR group, TMR + FES group, and TMR + NGF group according to TMR and whether they received FES treatment or NGF injection after surgery, and the recovery effect of rat neuromuscular function was assessed by analyzing EMG signals. Through the experiments, we confirmed that growth factor supplementation and low-frequency electrical stimulation can effectively promote the regeneration of the transplanted nerve as well as significantly enhance the motor function of the target muscle and have a positive effect on the regeneration of the transplanted nerve.

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生物和物理强化对靶向肌肉再支配的疗效

靶向肌肉再支配（TMR）是一种显微外科修复技术，用于重建远端神经和肌肉残端之间的解剖结构，为人工智能假肢提供更多的肌电信息。术后对患者失神经肌肉或近端神经残端进行功能性电刺激治疗，并注射神经生长因子，可有效促进神经再生和肌肉功能恢复。在本实验中，我们成功地建立了TMR大鼠模型，并将Sprague-Dawley（SD）成年雄性大鼠分为TMR组、TMR + FES组和TMR + NGF组根据TMR，术后是否接受FES治疗或注射NGF，并通过分析EMG信号评估大鼠神经肌肉功能的恢复效果。通过实验证实，补充生长因子和低频电刺激能有效促进移植神经的再生，并能显著增强靶肌的运动功能，对移植神经的重建有积极作用。

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