Estimating incidence rates of grouped HPV types: A systematic review and comparison of the impact of different epidemiological assumptions

Vita W. Jongen , Daniëla K. van Santen , Catharina J. Alberts , Maarten F. Schim van der Loeff
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引用次数: 3

Abstract

Background

Some studies on human papillomavirus (HPV) provide not only type-specific incidence rates (IR), but also IRs of HPV groupings (e.g. the nonavalent grouping). We made an inventory of the different approaches used to calculate such IRs and assessed their impact on the estimated IRs of HPV groupings.

Methods

We performed a systematic review assessing all approaches used in literature to estimate IRs. Subsequently we applied these approaches to data of a Dutch cohort study on HPV in men who have sex with men (H2M). IRs were estimated for six different HPV groupings.

Results

The systematic review yielded six different approaches (A-F) for estimating the IRs, varying in exclusion criteria at baseline, and the definitions of an incident event and person-time. Applying these approaches to the H2M dataset (n = 749), we found differences in the number of participants at risk, number of incidents events, person-time, and IR. For example, for the nonavalent grouping, depending on the approach chosen, the IR varied between 3.09 and 6.54 per 100 person-months.

Conclusion

In published studies different epidemiological assumptions are used to estimate IRs of grouped HPV types, leading to widely differing estimates of IRs. IRs between different studies may therefore not be comparable.

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估计分组HPV类型的发病率:不同流行病学假设影响的系统回顾和比较
一些关于人乳头瘤病毒(HPV)的研究不仅提供了类型特异性发病率(IR),而且还提供了HPV分组(如非价型组)的IR。我们对用于计算此类IRs的不同方法进行了盘点,并评估了它们对HPV分组估计IRs的影响。方法我们进行了一项系统综述,评估了文献中用于估计IRs的所有方法。随后,我们将这些方法应用于荷兰男男性行为者(H2M)中HPV队列研究的数据。估计了六种不同HPV组的ir。结果系统评价产生了六种不同的方法(A-F)来估计ir,这些方法在基线时的排除标准不同,以及事件事件和人时间的定义也不同。将这些方法应用于H2M数据集(n = 749),我们发现风险参与者数量、事件事件数量、人员时间和IR存在差异。例如,对于非价格组,根据所选择的方法,IR在每100人月3.09至6.54之间变化。在已发表的研究中,使用不同的流行病学假设来估计分组HPV类型的IRs,导致IRs估计差异很大。因此,不同研究之间的ir可能无法比较。
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来源期刊
自引率
0.00%
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0
审稿时长
14 weeks
期刊介绍: The official Journal of the International Papillomavirus Society Papillomavirus Research (PVR), the Journal of HPV and other Small DNA Tumor Viruses publishes innovative papers related to all aspects of papillomaviruses and other small DNA tumor viruses. The official journal of the International Papillomavirus Society, PVR is an open access publication that aims to bring together virologists, immunologists, epidemiologists and clinicians working in the booming field of HPV and animal papillomaviruses, polyomaviruses and other small DNA tumor viruses and their associated diseases, in order to foster and facilitate interdisciplinary communication. The journal welcomes original research articles, reviews, short communications, opinion articles and regional update reports on papillomaviruses and other tumor viruses in the following sections: a. Biology of papillomaviruses and related viruses from life cycle to cancer b. Epidemiology etiology and natural history studies c. Natural and induced immunity including vaccine research d. Intervention studies and strategies including i. Clinical studies and trials ii. HPV treatments iii. HPV vaccination programs iv. Diagnostics and screening e. Infection and disease prevention, modeling studies f. Guidelines and public health recommendations g. HPV Studies in special populations Regional and local studies on these viruses.
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