Changing Landscape of Cholangiocarcinoma

Abstract

The annual incidence of cholangiocarcinoma in the United States from 2001 to 2015 was 1.26 per 100,000 people per year. The incidence rates have increased over this time period, specifically for intrahepatic cholangiocarcinoma. According to the SEER data base, the average 5-year survival rate of localized intra-hepatic cholangiocarcinoma is 24% and that of extrahepatic is 15%. Native Americans have the highest incidence in the United States, about 6 times more than non-natives [1]. Occupational exposure to 1, 2 DCP and or dichloromethane has been documented in people working in the printing industry in Japan [2]. Chlonorchis Sinensis, oriental liver fluke; Opisthorchis Viverrini as well as chronic hepatolithiasis increase chance of developing the disease [3].