Calorimetry in Computed Tomography Beams.

IF 17.7 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-03-10 eCollection Date: 2021-01-01 DOI:10.6028/jres.126.054
H Heather Chen-Mayer, Ronald E Tosh, Fred B Bateman, Paul M Bergstrom, Brian E Zimmerman
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Abstract

A portable calorimeter for direct realization of absorbed dose in medical computed tomography (CT) procedures was constructed and tested in a positron emission tomography (PET) CT scanner. The calorimeter consists of two small thermistors embedded in a polystyrene (PS) cylindrical "core" (1.5 cm diameter) that can be inserted into a cylindrical high-density polyethylene (HDPE) phantom (30 cm diameter). The cylindrical design of core and phantom allows coaxial alignment of the system with the scanner rotation axis, which is necessary to minimize variations in dose that would otherwise occur as the X-ray source is rotated during scanning operations. The core can be replaced by a cylindrical ionization chamber for comparing dose measurement results. Measurements using the core and a calibrated thimble ionization chamber were carried out in a beam of 6 MV X-rays from a clinical accelerator and in 120 kV X-rays from a CT scanner. Doses obtained from the calorimeter and chamber in the 6 MV beam exhibited good agreement over a range of dose rates from 0.8 Gy/min to 4 Gy/min, with negligible excess heat. For the CT beam, as anticipated for these X-ray energies, the calorimeter response was complicated by excess heat from device components. Analyses done in the frequency domain and time domain indicated that excess heat increased calorimetric temperature rise by a factor of about 15. The calorimeter's response was dominated by dose to the thermistor, which contains high-atomic-number elements. Therefore, for future construction of calorimeters for CT beams, lower-atomic-number temperature sensors will be needed. These results serve as a guide for future alternative design of calorimeters toward a calorimetry absorbed dose standard for diagnostic CT.

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计算机断层扫描光束中的量热法
研制了一种用于医学计算机断层扫描(CT)程序中直接实现吸收剂量的便携式量热计,并在正电子发射断层扫描(PET) CT扫描仪上进行了测试。该量热计由两个嵌入聚苯乙烯(PS)圆柱形“芯”(直径1.5厘米)的小热敏电阻组成,该“芯”可以插入圆柱形高密度聚乙烯(HDPE)模体(直径30厘米)中。核心和幻体的圆柱形设计允许系统与扫描仪旋转轴同轴对准,这是必要的,以尽量减少在扫描操作期间x射线源旋转时可能发生的剂量变化。芯可替换为圆柱形电离室,用于比较剂量测量结果。在临床加速器的6毫伏x射线束和CT扫描仪的120千伏x射线束中,使用核心和校准的顶针电离室进行测量。从量热计和腔室在6毫伏光束中获得的剂量在0.8 Gy/min至4 Gy/min的剂量率范围内表现出良好的一致性,余热可以忽略不计。对于CT束,正如对这些x射线能量的预期,量热计的响应由于设备组件的多余热量而变得复杂。在频域和时域进行的分析表明,多余的热量使量热温升增加了约15倍。量热计的响应受热敏电阻的剂量控制,热敏电阻含有高原子序数的元素。因此,为了将来为CT光束建造量热计,将需要低原子序数的温度传感器。这些结果为将来设计量热计的备选方案提供了指导,为CT诊断提供了量热吸收剂量标准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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