Effect of curcumin on body mass index and glycemic indices in females with PCOS: a systematic review and meta-analysis of randomized controlled trial

IF 1 Q4 FOOD SCIENCE & TECHNOLOGY Nutrition & Food Science Pub Date : 2022-02-02 DOI:10.1108/nfs-11-2021-0334

M. Nouri, Sara Sohaei, M. N. Shalaby, S. Mehrabani, A. Ramezani, S. Faghih

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引用次数: 4

Abstract

Purpose This paper aims to assess the impact of curcumin supplementation body mass index and glycemic indices in women with polycystic ovary syndrome (PCOS). Design/methodology/approach A systematic search of the literature was conducted in PubMed, Scopus and ISI web of science to identify all randomized controlled trials (RCTs) published from the earliest record up to February 2021. The authors used a random-effects model to estimate pooled effect sizes. Findings A total of four potentially related clinical trials met the inclusion criteria which included a total of 198 participants. Random-effects meta-analysis showed significant effects of curcumin on fasting blood sugar (FBS) (−3.62 mg/dl, 95% CI [−5.65, −1.58], p-value < 0.001, I2 = 0.0%), insulin level (−1.67 µU/mL, 95% CI [−3.06, −0.28], p-value = 0.018, I2 = 0.0%) and homeostasis model of assessment insulin resistance (HOMA-IR) (−0.42, 95% CI [−0.76, −0.09], p-value < 0.01, I2 = 0.0%). No evidence of publication bias was discovered in the meta-analyses. Originality/value Present systematic review and meta-analysis of RCTs showed beneficial effects of curcumin consumption on FBS, insulin level and HOMA-IR in patients with PCOS. However, further large-scale studies are needed to confirm these results.

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姜黄素对女性多囊卵巢综合征患者体重指数和血糖指数的影响:一项随机对照试验的系统评价和荟萃分析

目的本文旨在评估补充姜黄素对多囊卵巢综合征（PCOS）女性的体重指数和血糖指数的影响。设计/方法/方法在PubMed、Scopus和ISI科学网上对文献进行了系统检索，以确定从最早记录到2021年2月发表的所有随机对照试验（RCT）。作者使用随机效应模型来估计合并效应的大小。发现共有四项潜在相关的临床试验符合纳入标准，共有198名参与者。随机效应荟萃分析显示姜黄素对空腹血糖（FBS）有显著影响（−3.62 mg/dl，95%置信区间[−5.65，−1.58]，p值<0.001，I2=0.0%），胰岛素水平（−1.67µU/mL，95%置信区间[-3.06，−0.28]，p值=0.018，I2=0.0%）和胰岛素抵抗稳态评估模型（HOMA-IR）（−0.42，95%置信度[-0.76，−0.09]，p价值<0.01，I2=0.00%）。荟萃分析中未发现发表偏倚的证据。来源/价值目前对随机对照试验的系统综述和荟萃分析显示姜黄素具有有益作用PCOS患者对FBS、胰岛素水平和HOMA-IR的消耗。然而，还需要进一步的大规模研究来证实这些结果。

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来源期刊

Nutrition & Food Science FOOD SCIENCE & TECHNOLOGY-

CiteScore

2.80

自引率

8.30%

发文量

期刊介绍： Nutrition & Food Science* (NFS) is an international, double blind peer-reviewed journal offering accessible and comprehensive coverage of food, beverage and nutrition research. The journal draws out the practical and social applications of research, demonstrates best practice through applied research and case studies and showcases innovative or controversial practices and points of view. The journal is an invaluable resource to inform individuals, organisations and the public on modern thinking, research and attitudes to food science and nutrition. NFS welcomes empirical and applied research, viewpoint papers, conceptual and technical papers, case studies, meta-analysis studies, literature reviews and general reviews which take a scientific approach to the following topics: -Attitudes to food and nutrition -Healthy eating/ nutritional public health initiatives, policies and legislation -Clinical and community nutrition and health (including public health and multiple or complex co-morbidities) -Nutrition in different cultural and ethnic groups -Nutrition during pregnancy, lactation, childhood, and young adult years -Nutrition for adults and older people -Nutrition in the workplace -Nutrition in lower and middle income countries (incl. comparisons with higher income countries) -Food science and technology, including food processing and microbiological quality -Genetically engineered foods -Food safety / quality, including chemical, physical and microbiological analysis of how these aspects effect health or nutritional quality of foodstuffs