Atypical fibrous histiocytomas and pleomorphic fibroma-type lesions in a patient with li-fraumeni syndrome

IF 0.4 Q3 MEDICINE, GENERAL & INTERNAL Proceedings of Singapore Healthcare Pub Date : 2023-01-18 DOI:10.1177/20101058231152047
Logaswari M, M. Koh, K. Sittampalam
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引用次数: 0

Abstract

Atypical fibrous histiocytomas are an uncommon but benign variant of dermatofibroma where the neoplastic cells can feature cytological atypia constituted by prominent nuclear enlargement, pleomorphism and multinucleated giant cells. Though these can have a degree of atypia, they have a benign course and a failure to recognize these tumors as benign can lead to misdiagnosis and overtreatment, particularly in patients with Li-Fraumeni syndrome who are known to be predisposed to various malignancies. Here, we report a patient with atypical fibrous histiocytomas and multiple pleomorphic fibroma-type lesions in the setting of Li-Fraumeni syndrome.
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非典型纤维组织细胞瘤和多形性纤维瘤型病变1例li- frameni综合征
非典型纤维组织细胞瘤是一种罕见但良性的皮肤纤维瘤,其肿瘤细胞具有细胞学上的非典型性,由明显的核增大、多形性和多核巨细胞组成。虽然这些可能有一定程度的非典型性,但它们具有良性病程,未能识别这些肿瘤为良性可能导致误诊和过度治疗,特别是对于已知易患各种恶性肿瘤的Li-Fraumeni综合征患者。在此,我们报告一位患有非典型纤维组织细胞瘤和多发性多形性纤维瘤型病变的Li-Fraumeni综合征患者。
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来源期刊
Proceedings of Singapore Healthcare
Proceedings of Singapore Healthcare MEDICINE, GENERAL & INTERNAL-
CiteScore
0.90
自引率
0.00%
发文量
42
审稿时长
15 weeks
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