Autophagy in Kidney Disease.

IF 15.7 1区 医学 Q1 PHYSIOLOGY Annual review of physiology Pub Date : 2020-02-10 DOI:10.1146/annurev-physiol-021119-034658
Mary E. Choi
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引用次数: 82

Abstract

Autophagy is a cellular homeostatic program for the turnover of cellular organelles and proteins, in which double-membraned vesicles (autophagosomes) sequester cytoplasmic cargos, which are subsequently delivered to the lysosome for degradation. Emerging evidence implicates autophagy as an important modulator of human disease. Macroautophagy and selective autophagy (e.g., mitophagy, aggrephagy) can influence cellular processes, including cell death, inflammation, and immune responses, and thereby exert both adaptive and maladaptive roles in disease pathogenesis. Autophagy has been implicated in acute kidney injury, which can arise in response to nephrotoxins, sepsis, and ischemia/reperfusion, and in chronic kidney diseases. The latter includes comorbidities of diabetes and recent evidence for chronic obstructive pulmonary disease-associated kidney injury. Roles of autophagy in polycystic kidney disease and kidney cancer have also been described. Targeting the autophagy pathway may have therapeutic benefit in the treatment of kidney disorders. Expected final online publication date for the Annual Review of Physiology, Volume 82 is February 10, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
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肾脏疾病中的自噬。
自噬是一种细胞器和蛋白质周转的细胞稳态程序,其中双膜囊泡(自噬体)螯合细胞质货物,随后将其输送到溶酶体进行降解。新出现的证据表明自噬是人类疾病的重要调节因子。大自噬和选择性自噬(如线粒体自噬、聚集性自噬)可以影响细胞过程,包括细胞死亡、炎症和免疫反应,从而在疾病发病机制中发挥适应和不适应作用。自噬与急性肾损伤和慢性肾脏疾病有关,急性肾损伤可因肾毒素、败血症和缺血/再灌注而发生。后者包括糖尿病合并症和慢性阻塞性肺病相关肾损伤的最新证据。自噬在多囊肾病和肾脏癌症中的作用也已被描述。靶向自噬途径在治疗肾脏疾病方面可能具有治疗益处。《生理学年度评论》第82卷预计最终在线出版日期为2020年2月10日。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual review of physiology
Annual review of physiology 医学-生理学
CiteScore
35.60
自引率
0.00%
发文量
41
期刊介绍: Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.
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