Hemocompatibility and hemodynamic comparison of two centrifugal LVADs: HVAD and HeartMate3

IF 3 3区医学 Q2 BIOPHYSICS Biomechanics and Modeling in Mechanobiology Pub Date : 2023-01-17 DOI:10.1007/s10237-022-01686-y

Antonio Gil, Roberto Navarro, Pedro Quintero, Andrea Mares

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Abstract

Mechanical circulatory support using ventricular assist devices is a common technique for treating patients suffering from advanced heart failure. The latest generation of devices is characterized by centrifugal turbopumps which employ magnetic levitation bearings to ensure a gap clearance between moving and static parts. Despite the increasing use of these devices as a destination therapy, several long-term complications still exist regarding their hemocompatibility. The blood damage associated with different pump designs has been investigated profoundly in the literature, while the hemodynamic performance has been hardly considered. This work presents a novel comparison between the two main devices of the latest generation–HVAD and HM3–from both perspectives, hemodynamic performance and blood damage. Computational fluid dynamics simulations are performed to model the considered LVADs, and computational results are compared to experimental measurements of pressure head to validate the model. Enhanced performance and hemocompatibility are detected for HM3 owing to its design incorporating more conventional blades and larger gap clearances.

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两种离心式lvad: HVAD和HeartMate3的血液相容性和血流动力学比较

使用心室辅助装置的机械循环支持是治疗晚期心力衰竭患者的常用技术。最新一代设备的特点是离心涡轮泵采用磁悬浮轴承，以确保移动和静态部件之间的间隙。尽管越来越多地使用这些装置作为目的治疗，但它们的血液相容性仍然存在一些长期并发症。不同泵设计对血液损伤的影响已在文献中进行了深入的研究，但其血流动力学性能却很少被考虑。这项工作从血流动力学性能和血液损伤两个角度对最新一代的两种主要装置hvad和hm3进行了新颖的比较。通过计算流体动力学仿真对所考虑的lvad进行了建模，并将计算结果与压头的实验测量结果进行了比较，以验证模型的有效性。由于HM3的设计采用了更传统的叶片和更大的间隙，因此检测到HM3的性能和血液相容性得到了增强。

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来源期刊

Biomechanics and Modeling in Mechanobiology 工程技术-工程：生物医学

CiteScore

7.10

自引率

8.60%

发文量

119

审稿时长

6 months

期刊介绍： Mechanics regulates biological processes at the molecular, cellular, tissue, organ, and organism levels. A goal of this journal is to promote basic and applied research that integrates the expanding knowledge-bases in the allied fields of biomechanics and mechanobiology. Approaches may be experimental, theoretical, or computational; they may address phenomena at the nano, micro, or macrolevels. Of particular interest are investigations that (1) quantify the mechanical environment in which cells and matrix function in health, disease, or injury, (2) identify and quantify mechanosensitive responses and their mechanisms, (3) detail inter-relations between mechanics and biological processes such as growth, remodeling, adaptation, and repair, and (4) report discoveries that advance therapeutic and diagnostic procedures. Especially encouraged are analytical and computational models based on solid mechanics, fluid mechanics, or thermomechanics, and their interactions; also encouraged are reports of new experimental methods that expand measurement capabilities and new mathematical methods that facilitate analysis.