Effects of Diesel Combustion Nanoparticles on Oxidative Stress Markers among the Exposures

Abstract

Objective: To study the Oxidative stress response Introduction: Exposure to various inflammatory agents causes oxidative stress in humans and is the route cause numerous chronic degenerative diseases. Every organism on Earth has been exposed to small and minute foreign particles by direct contact and/or by inhalation. They enter the organ system of humans and animals and potentially disrupt the cellular processes, interact with membranes, cell organelles, DNA, and other proteins to establish a series of dynamic bio-physico-chemical interactions and results in bio-compatible or bio-adverse outcomes causing diseases and/or disorders. Although studies are available on lipid peroxidation products and the antioxidant status in experimental animals, a detailed report with respect to oxidative stress markers on human exposed to diesel combustion nanoparticles is meagre. We aimed to study the variation in oxidative stress markers among exposures. Methodology: The study was conducted among 500 male garage workers of age group 25-40years with exposure for 6-8hrs a day without using any protective aids during work, for 6-12years and 300 controls. Serum oxidative stress markers were estimated and compared. Results: A significant variation among the oxidative stress markers were observed among the exposures with surge in MDA and reduction in SOD and CAT. Conclusion: Oxidative stress markers can be good biomonitoring factor in primary care.Key words: Diesel combustion nanoparticles, oxidative stress markers, superoxide dismutase, catalase, lipid peroxidation, melanaldehyde