Liliana Liverani , Theresa Reiter , Kai Zheng , Zuzana Neščáková , Aldo R. Boccaccini
{"title":"Copper-doped cotton-like malleable electrospun bioactive glass fibers for wound healing applications","authors":"Liliana Liverani , Theresa Reiter , Kai Zheng , Zuzana Neščáková , Aldo R. Boccaccini","doi":"10.1016/j.mlblux.2022.100133","DOIUrl":null,"url":null,"abstract":"<div><p>The combination of electrospinning and sol-gel methods is attracting the interest of the scientific community for developing three-dimensional bioactive glass (BG)-based fibers. This paper reports the fabrication of cotton-like copper-doped BG fibers by combining electrospinning and sol-gel techniques. Acellular bioactivity in simulated body fluid, ion release, cell viability and scratch cell tests were performed. Results showed that copper was successfully incorporated in the fibers and Cu ions were released in limited concentration over seven days. The presence of copper delayed the mineralization of the fibers upon immersion in simulated body fluid (SBF), but it did not affect keratinocyte viability and migration. Wound closure in the scratch cell test was achieved in 48 h for all the investigated samples.</p></div>","PeriodicalId":18245,"journal":{"name":"Materials Letters: X","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590150822000138/pdfft?md5=5d7baefa7e4ba4749b8bdbb70c3b9788&pid=1-s2.0-S2590150822000138-main.pdf","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Letters: X","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590150822000138","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 8
Abstract
The combination of electrospinning and sol-gel methods is attracting the interest of the scientific community for developing three-dimensional bioactive glass (BG)-based fibers. This paper reports the fabrication of cotton-like copper-doped BG fibers by combining electrospinning and sol-gel techniques. Acellular bioactivity in simulated body fluid, ion release, cell viability and scratch cell tests were performed. Results showed that copper was successfully incorporated in the fibers and Cu ions were released in limited concentration over seven days. The presence of copper delayed the mineralization of the fibers upon immersion in simulated body fluid (SBF), but it did not affect keratinocyte viability and migration. Wound closure in the scratch cell test was achieved in 48 h for all the investigated samples.
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