Recent progress on the [3+2] cycloaddition route for the synthesis of all-carbon quaternary stereocentres

Abstract

Construction of all-carbon quaternary centres is an important task in organic synthesis. In spite of the challenges associated with the Csp3-Csp3 bond constructions in a sterically constrained environment, significant advances have been made in this area. Among the latter, catalytic and non-catalytic [3+2] cycloaddition approach has gained wide attention recently. This short review summarizes the [3+2] cycloaddition reactions reported during the period 2016-2022 for the synthesis of molecules possessing one or more all-carbon quaternary stereocentre