{"title":"Sodium selenite addition promotes the proliferation of bovine\nmammary epithelial cells through the Akt-mTOR\nsignalling pathway","authors":"J. Zhang, Y. Liu, L. Bu, Q. Liu, C. Pei, G. Guo","doi":"10.22358/jafs/159458/2023","DOIUrl":null,"url":null,"abstract":". The experiment was designed to evaluate the effect of sodium selenite (Na 2 SeO 3 ) on the proliferation of bovine mammary gland epithelial cells (BMECs), and to assess the underlying mechanisms. The addition of Na 2 SeO 3 at doses ranging from 18 to 140 nM stimulated BMEC proliferation. Nevertheless, high doses of Na 2 SeO 3 (> 70 nM) did not further stimulate BMEC proliferation compared to 35 nM Na 2 SeO 3 . Therefore, the addition of 35 nM Na 2 SeO 3 increased the proportion of epithelial cells undergoing DNA replication, mRNA expression of proliferating cell nuclear antigen (PCNA), Cyclin A2","PeriodicalId":14919,"journal":{"name":"Journal of Animal and Feed Sciences","volume":" ","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Animal and Feed Sciences","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.22358/jafs/159458/2023","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}
引用次数: 0
Abstract
. The experiment was designed to evaluate the effect of sodium selenite (Na 2 SeO 3 ) on the proliferation of bovine mammary gland epithelial cells (BMECs), and to assess the underlying mechanisms. The addition of Na 2 SeO 3 at doses ranging from 18 to 140 nM stimulated BMEC proliferation. Nevertheless, high doses of Na 2 SeO 3 (> 70 nM) did not further stimulate BMEC proliferation compared to 35 nM Na 2 SeO 3 . Therefore, the addition of 35 nM Na 2 SeO 3 increased the proportion of epithelial cells undergoing DNA replication, mRNA expression of proliferating cell nuclear antigen (PCNA), Cyclin A2
期刊介绍：
Journal of Animal and Feed Sciences (JAFS, J. Anim. Feed Sci.) has been published by the Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences in Jabłonna (Poland) since 1991. It is a continuation of the Polish-language journal Roczniki Nauk Rolniczych. Seria B, Zootechniczna published by the Polish Academy of Sciences since 1969.
JAFS is an international scientific journal published quarterly, about 40 papers per year including original papers, short communications and occasionally reviews. All papers are peer-reviewed and related to basic and applied researches in the field of animal breeding and genetics, physiology of nutrition, animal feeding, feed technology and food preservation. The journal distinguishes the multidisciplinary nature of physiological and nutritional sciences and so includes papers specialized in all fields connected with animal well-being, including molecular and cell biology and the emerging area of genetics.
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