Progress on clinical research of hyperthermia combined with radiation therapy

Liqing Zou, Yida Li, Xi Yang
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Abstract

Hyperthermia has been a research hot spot since it was approved by FDA as one of the 5 major therapeutic modalities for tumor since 1989. Pre-clinicaland clinical researches have confirmed the prominent radiosensitizing effect of hyperthermia. In this article, the research progress on hyperthermia combined with radiation therapy was summarized based upon clinical evidence. The challenges and issues during the procedure of hyperthermia combined with radiation therapy were analyzed from the perspectives of treatment temperature, frequency and interval time of hyperthermia, interval time and time sequence between hyperthermia and radiation therapy, etc. Besides, the application progress and prospect of hyperthermia combined with radiation therapy were reviewed, aiming to provide clinical evidence for the combination of hyperthermia and radiation therapy. Key words: Neoplasm/radiotherapy; Neoplasm/hyperthermia; Neoplasm/hyperthermia combined with radiation therapy; Research progress
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热疗联合放射治疗的临床研究进展
自1989年被美国食品药品监督管理局批准为肿瘤五大治疗方式之一以来,热疗一直是研究热点。临床前和临床研究已经证实热疗具有显著的放射增敏作用。本文根据临床证据,综述了热疗联合放射治疗的研究进展。从热疗的治疗温度、热疗的频率和间隔时间、热疗与放疗的间隔时间和时序等方面分析了热疗联合放疗过程中面临的挑战和问题,目的为热疗与放射治疗相结合提供临床依据。关键词:肿瘤/放疗;肿瘤/热疗;肿瘤/热疗结合放射治疗;研究进展
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期刊介绍: The Chinese Journal of Radiation Oncology is a national academic journal sponsored by the Chinese Medical Association. It was founded in 1992 and the title was written by Chen Minzhang, the former Minister of Health. Its predecessor was the Chinese Journal of Radiation Oncology, which was founded in 1987. The journal is an authoritative journal in the field of radiation oncology in my country. It focuses on clinical tumor radiotherapy, tumor radiation physics, tumor radiation biology, and thermal therapy. Its main readers are middle and senior clinical doctors and scientific researchers. It is now a monthly journal with a large 16-page format and 80 pages of text. For many years, it has adhered to the principle of combining theory with practice and combining improvement with popularization. It now has columns such as monographs, head and neck tumors (monographs), chest tumors (monographs), abdominal tumors (monographs), physics, technology, biology (monographs), reviews, and investigations and research.
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