Mitochondrial dysfunction in patients with urogenital disease

IF 0.8 Q4 UROLOGY & NEPHROLOGY Urological Science Pub Date : 2021-07-01 DOI:10.4103/uros.uros_47_21
Tzu-Yu Chuang, Te-Wei Chang, Shiou-Sheng Chen, Chang-Chi Chang, W. Cheng, Yau-Huei Wei
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引用次数: 3

Abstract

Mitochondria are intracellular organelles responsible for the production of the majority of adenosine triphosphate (ATP). In addition to energy production, mitochondria also contribute to cellular apoptosis, the regulation of intracellular Ca2+ homeostasis, signaling through reactive oxygen species (ROS), and the coordination of the cell cycle. The prevalence rate of primary mitochondrial disease was estimated at nearly 1:5000. In this review, we have integrated recent evidence to discuss new insights into how mitochondrial dysregulation plays a role in bladder dysfunction, reproductive disorder and the correlation between mtDNA mutation and bladder cancer.
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泌尿生殖系统疾病患者的线粒体功能障碍
线粒体是负责产生大部分三磷酸腺苷(ATP)的细胞内细胞器。除了能量产生外,线粒体还参与细胞凋亡、细胞内Ca2+稳态的调节、通过活性氧(ROS)发出信号以及细胞周期的协调。原发性线粒体疾病的患病率估计接近1:5000。在这篇综述中,我们整合了最近的证据,以讨论线粒体失调如何在膀胱功能障碍、生殖障碍中发挥作用,以及mtDNA突变与膀胱癌症之间的相关性。
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来源期刊
Urological Science
Urological Science UROLOGY & NEPHROLOGY-
CiteScore
1.20
自引率
0.00%
发文量
26
审稿时长
6 weeks
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