Functionally Tailored Electro-Sensitive Poly(Acrylamide)-g-Pectin Copolymer Hydrogel for Transdermal Drug Delivery Application: Synthesis, Characterization, In-vitro and Ex-vivo Evaluation

Q2 Pharmacology, Toxicology and Pharmaceutics Drug Delivery Letters Pub Date : 2020-08-31 DOI:10.2174/2210303110666200206114632
S. B. Patil, Syed Z. Inamdar, K. R. Reddy, A. Raghu, K. G. Akamanchi, A. Inamadar, Kusal K. Das, R. V. Kulkarni
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引用次数: 46

Abstract

To develop electro-sensitive transdermal drug delivery systems (ETDDS) using polyacrylamide-grafted-pectin (PAAm-g-PCT) copolymer hydrogel for rivastigmine delivery. Free radical polymerization and alkaline hydrolysis technique was employed to synthesize PAAm-g-PCT copolymer hydrogel. The PAAm-g-PCT copolymeric hydrogel was used as a reservoir and cross-linked blend films of PCT and poly(vinyl alcohol) as rate-controlling membranes (RCMs) to prepare ETDDS. The pH of the hydrogel reservoir was found to be in the range of 6.81 to 6.93 and drug content was 89.05 to 96.29%. The thickness of RCMs was in the range of 51 to 99 μ and RCMs showed permeability behavior against water vapors. There was a reduction in the water vapor transmission rate as the glutaraldehyde (GA) concentration was increased. The drug permeation rate from the ETDDS was enhanced under the influence of electric stimulus against the absence of an electric stimulus. The increase in flux by 1.5 fold was recorded with applied electric stimulus. The reduction in drug permeability observed when the concentration of GA was increased. Whereas, the permeability of the drug was augmented as an electric current was changed from 2 to 8 mA. The pulsatile drug release under “on– off” cycle of electric stimulus witnessed a faster drug release under ‘on’ condition and it was slow under ‘off’ condition. The alteration in skin composition after electrical stimulation was confirmed through histopathology studies. The PAAm-g-PCT copolymer hydrogel is a useful carrier for transdermal drug delivery activated by an electric signal to provide on-demand release of rivastigmine.
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经皮给药功能定制电敏感聚(丙烯酰胺)-g-果胶共聚物水凝胶:合成、表征、体外和离体评价
以聚丙烯酰胺接枝果胶(PAAm-g-PCT)共聚物水凝胶为原料,开发了利瓦斯汀电敏透皮给药系统(ETDDS)。采用自由基聚合和碱水解技术合成了PAAm-g-PCT共聚物水凝胶。以PAAm-g-PCT共聚水凝胶为储层,以PCT和聚乙烯醇的交联共混膜为速率控制膜制备ETDDS。水凝胶储层的pH值在6.81至6.93之间,药物含量为89.05至96.29%蒸汽。随着戊二醛(GA)浓度的增加,水蒸气透过率降低。在没有电刺激的情况下,在电刺激的影响下,ETDDS的药物渗透速率增强。在施加电刺激的情况下,流量增加了1.5倍。当GA的浓度增加时,观察到药物渗透性的降低。然而,当电流从2mA变为8mA时,药物的渗透性会增加。在电刺激的“开-关”循环下,药物的脉冲释放在“开”条件下更快,在“关”条件下缓慢。通过组织病理学研究证实了电刺激后皮肤成分的变化。PAAm-g-PCT共聚物水凝胶是一种有用的透皮药物递送载体,通过电信号激活以提供利瓦斯汀的按需释放。
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来源期刊
Drug Delivery Letters
Drug Delivery Letters Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
CiteScore
1.70
自引率
0.00%
发文量
30
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