Efficacy of pre-operative silodosin on flexible ureteroscopy procedure: A randomized controlled study.

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-05-09 eCollection Date: 2023-01-01 DOI:10.1080/2090598X.2023.2208790

Hussein Shaher, Ahmed Sebaey, Ahmed Mahmoud Abd Albaky, Mahmoud Abd Alazeem Mahmoud, Ashraf Mohammed Abd Elaal

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Abstract

Objectives: To evaluate the impact of silodosin on stages of flexible ureteroscopy (F-URS) procedures, complications, and stone-free rate (SFR).

Patients and methods: A prospective, randomized, controlled comparison research was conducted on 106 patients who were randomly allocated into two groups: the study group (52 patients) received F-URS with preoperative daily uptake of 8 mg silodosin for 10 days, and the control group (54 patients) received F- URS without silodosin uptake. Two patients were lost during the follow up in the study group and four patients were also lost in the controls.

Results: Operative time, application access sheath time (AAST), entrance to ureteric orifice time (ETUOT), and entrance to bladder time (ETBT) were significantly lower in the study group compared to controls. Meanwhile, F-URS time & laser time was higher in the study group compared to controls but without statistically significant difference. Complications were insignificalty different between both studied goups with no impact on SFR.

Conclusion: Before ureteroscopy, silodosin, an adjunctive alpha-blocker therapy, was successful in treating stones resulting in shortening the procedural time, with no impact on SFR or complication rate.

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术前西洛酮对柔性输尿管镜手术的疗效：一项随机对照研究

目的：评估西洛多辛对柔性输尿管镜（F-URS）手术阶段、并发症和无结石率（SFR）的影响：评估西洛多辛对柔性输尿管镜（F-URS）手术阶段、并发症和无结石率（SFR）的影响：对106名患者进行了前瞻性、随机对照对比研究，并将其随机分为两组：研究组（52名患者）接受输尿管软镜检查，术前每天服用8毫克西洛多辛，为期10天；对照组（54名患者）接受输尿管软镜检查，不服用西洛多辛。研究组有两名患者在随访期间死亡，对照组也有四名患者死亡：结果：与对照组相比，研究组的手术时间、应用入路鞘时间（AAST）、输尿管口入口时间（ETUOT）和膀胱入口时间（ETBT）均显著缩短。同时，研究组的 F-URS 时间和激光时间高于对照组，但无统计学差异。研究组和对照组的并发症差异不大，对 SFR 也没有影响：结论：在输尿管镜检查前，西洛多辛作为一种α-受体阻滞剂的辅助疗法可成功治疗结石，从而缩短手术时间，但对 SFR 或并发症发生率没有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.