{"title":"Are we ready for pig-to-human clinical xenotransplantation trials?","authors":"Laichun Zhang, L. Ling","doi":"10.4067/s1726-569x2022000100149","DOIUrl":null,"url":null,"abstract":": The invention and widely use of organ allotransplantation provides effective treatment of some originally fetal diseases such as liver/kidney failure and has saved million of lives around the globe. However, the scarcity of human organs has caused many patients, who could have been treated, to die while waiting for suitable organs around the world. Pig-to hu- man xenotransplantation provides a potential solution to solve this tough problem. Pig organs have been considered as major sources of xenotransplantation because of the sufficient number of donors, the sizes of organs, and physiologically structural similarities. However, xenotransplantation also has some problems, such as the possibility of spreading animal diseases to human, the interspecies immunological barrier, organs of animal origin challenging human nature, and potential informed consent issues. This article will discuss these potential issues and to see whether it is the suitable time to conduct clinical xenotransplantation trials in humans.","PeriodicalId":29643,"journal":{"name":"Acta Bioethica","volume":null,"pages":null},"PeriodicalIF":0.5000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Bioethica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4067/s1726-569x2022000100149","RegionNum":4,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ETHICS","Score":null,"Total":0}
引用次数: 0
Abstract
: The invention and widely use of organ allotransplantation provides effective treatment of some originally fetal diseases such as liver/kidney failure and has saved million of lives around the globe. However, the scarcity of human organs has caused many patients, who could have been treated, to die while waiting for suitable organs around the world. Pig-to hu- man xenotransplantation provides a potential solution to solve this tough problem. Pig organs have been considered as major sources of xenotransplantation because of the sufficient number of donors, the sizes of organs, and physiologically structural similarities. However, xenotransplantation also has some problems, such as the possibility of spreading animal diseases to human, the interspecies immunological barrier, organs of animal origin challenging human nature, and potential informed consent issues. This article will discuss these potential issues and to see whether it is the suitable time to conduct clinical xenotransplantation trials in humans.
期刊介绍：
Acta Bioethica is a biannual publication by the Interdisciplinary Center for Studies in Bioethics of the University of Chile (ISSN 0717-5906, press edition, y 1726-569-X, electronic edition), which publishes in three languages: Spanish, English and Portuguese.
Indexed in Science Citation Index (SCI), Scopus, Lilacs, SciELO y Latindex, and in database from several Institutions; it constitutes a pluralistic source of perspectives and an important tribune which accepts the contributions of authors compromised with the interdisciplinary study of ethical determinants and consequences of techno scientific research.
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