DoE Based Optimization of Oral In-Situ Gel Containing Dandelion Leaf Extract

Abstract

The present study developed oral in-situ gel containing the leaf extract of Taraxacum officinale (T.O.) using the Design of the experiment. Background: Peptic ulcer disease is an epidemic in the 19th and early 20th centuries. The application of herbal drugs for peptic diseases is an attractive area for research and implementation as compared to the allopathic system in the recent era. From the number of plants, the antioxidant effect of an aqueous extract of Taraxacum officinale that is Dandelion leaf was proven by an animal study in some previous literature. However, most of the marketed preparations consist root extract primarily used for detoxification of liver incomparision to the leaf extract having nonspecific application. Hence the aqueous extract of Dandelion leaf was taken as the active ingredient in the formulation. Over the past 30 years, greater attention has been focused on the development of controlled and sustained drug delivery systems. The development of in situ gel systems has received considerable attention over the past few years due to the number of advantages. Therefore taking, the merits of herbal ingredients with drug delivery technology was developed using statistical analysis Here, the concentration of Sodium alginate, Concentration of xanthan gum, and concentration of HPMC K15 M was taken as the factors and viscosity as well as drug release (Total phenol content) in 10 h were selected as the responses The designed batch consisting of 1.711% w/v sodium alginate, 0.727% w/v xanthan gum, and 0.869% w/v HPMC K15M was selected as the optimized one as per the software and the viscosity and % drug release in 10 h were found to be 299.5cps and 70.2% respectively. Other evaluation parameters such as gelling capacity, floating parameters, and stability were also found to be good for the designed batches. The optimized in-situ gel was found to be thoughtful for extending the floating of drug incorporated in the formulation as well as residence time in the stomach for sustaining the drug release