Where are we today with machine perfusion of liver in donation after circulatory death liver transplantation?

Q4 Medicine Transplantation Reports Pub Date : 2022-12-01 DOI:10.1016/j.tpr.2022.100111
Badi Rawashdeh, Joohyun Kim, Johnny C. Hong
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引用次数: 1

Abstract

Livers procured from donors after circulatory death (DCD) have increasingly been used for liver transplantation (LT) to address the organ crisis. While DCD LT increases patient access to life-saving treatment, this practice creates risks for recipients, including primary allograft non-function, early allograft dysfunction, and ischemic cholangiopathy. These complications are due to the unique ischemia and reperfusion injury related to different phases of organ procurement and preservation in DCD. Therefore, substantial research efforts and innovations on DCD LT have primarily aimed at reducing these complications. One such advance is the utilization of ex vivo machine perfusion of the donor liver in DCD LT. This review focused on the data from clinical trials and studies in human DCD LT.

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机器灌注肝在循环死亡后肝移植捐献中的应用进展如何?
循环性死亡(DCD)后从供体获得的肝脏越来越多地用于肝移植(LT),以解决器官危机。虽然DCD LT增加了患者获得挽救生命的治疗的机会,但这种做法给受者带来了风险,包括原发性同种异体移植物无功能、早期同种异体移植物功能障碍和缺血性胆管病。这些并发症是由于DCD中器官获取和保存不同阶段特有的缺血再灌注损伤所致。因此,DCD LT的大量研究工作和创新主要旨在减少这些并发症。其中一个进步是在DCD LT中利用供肝离体机器灌注。本文主要综述了临床试验和人类DCD LT研究的数据。
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来源期刊
Transplantation Reports
Transplantation Reports Medicine-Transplantation
CiteScore
0.60
自引率
0.00%
发文量
24
审稿时长
101 days
期刊介绍: To provide to national and regional audiences experiences unique to them or confirming of broader concepts originating in large controlled trials. All aspects of organ, tissue and cell transplantation clinically and experimentally. Transplantation Reports will provide in-depth representation of emerging preclinical, impactful and clinical experiences. -Original basic or clinical science articles that represent initial limited experiences as preliminary reports. -Clinical trials of therapies previously well documented in large trials but now tested in limited, special, ethnic or clinically unique patient populations. -Case studies that confirm prior reports but have occurred in patients displaying unique clinical characteristics such as ethnicities or rarely associated co-morbidities. Transplantation Reports offers these benefits: -Fast and fair peer review -Rapid, article-based publication -Unrivalled visibility and exposure for your research -Immediate, free and permanent access to your paper on Science Direct -Immediately citable using the article DOI
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