Safety of intravenous iodinated contrast medium injection in rabbits undergoing conscious computed tomography.

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-03-04 eCollection Date: 2022-12-01 DOI:10.1002/vro2.31

Ingrid Isaac, Jenna Richardson, Tiziana Liuti, Maurizio Longo

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Abstract

Background: Contrast media in CT is widely used in dogs and cats to provide superior tissue delineation and increase the diagnostic capabilities. These contrast-enhanced imaging techniques are gaining popularity in rabbits; published studies reporting the safety of doing so are lacking.

Methods: This retrospective observational study aimed to determine the incidence of adverse events following the intravenous administration of iodinated non-ionic contrast medium in 350 rabbits. The medical records of this subset of rabbits admitted between January 2009 and November 2018, that underwent CT examination and received intravenous contrast media, were evaluated.

Results: From the 350 rabbits, 342 rabbits were still alive 7 days after the scan. A total of eight rabbits died within 7 days of the scan, seven of which within the first 24 h. All deaths were presumed to be sequelae to the diseases they were being investigated for and not thought to be related to the administration of intravenous contrast medium.

Conclusions: The results indicated that the use of intravenous non-iodinated contrast medium was well tolerated and safe in rabbits undergoing conscious CT examination.

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兔进行有意识计算机断层扫描时静脉注射碘造影剂的安全性

背景CT造影剂被广泛应用于狗和猫，以提供优越的组织描绘和提高诊断能力。这些对比度增强成像技术在兔子中越来越受欢迎;发表的研究报告缺乏这样做的安全性。方法回顾性观察350只家兔静脉注射碘化非离子造影剂后不良事件的发生率。对2009年1月至2018年11月期间入院的这组家兔的医疗记录进行评估，这些家兔接受了CT检查和静脉造影剂注射。结果350只家兔中，342只在扫描后7天仍存活。在扫描后的7天内，共有8只兔子死亡，其中7只在前24小时内死亡。所有的死亡都被认为是所调查疾病的后遗症，与静脉注射造影剂无关。结论在家兔进行意识CT检查时，静脉注射非碘造影剂具有良好的耐受性和安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.