Dietary Supplement Use in Live Kidney Donors and Recipients

Abstract

Background: Dietary supplement use in living kidney donors (LKDs) and kidney transplant recipients (KTRs) provides care challenges due to drug interactions, limited data, and lack of management guidelines. The study purposes were to describe supplement use patterns and intra/postoperative complications in these populations. Methods: A single-center retrospective review of LKDs and KTRs from September 2016 – 2018 was conducted. Supplement information was collected at evaluation and preoperative visits. Supplement relationship to intra/postoperative complications was graded by Naranjo Adverse Drug Reaction Probability Scale. Results: One hundred and fi fty-seven LKDs met inclusion with an average age of 45 (SD 11) years. Thirty-seven LKDs (24%) reported supplement use pre-donation. One hundred and eleven KTRs met inclusion with an average age of 46 (SD 13) years and 21 (19%) reported supplement use pre-transplant. No signi fi cant differences in sex, ethnicity, or education were found between LKDs or KTRs using supplements vs none. One complication in an LKD was “ possibly ” related to supplement use vs none in KTRs. Conclusion: Transplant providers should screen for supplement use in LKDs and KTRs at both the evaluation and pre-operative visits and review perioperative management. The low dietary supplement-related intra/post complication rate may be due to discontinuation of supplements preoperatively. administered herbal or complementary nutritional products (including botanicals, microbial additives, and amino acids), excluding micronutrients (vitamins/minerals), and foods/drinks.