The effect of carvacrol on tramadol-induced oxidative renal injury in rats: biochemical and histopathological evaluation

IF 0.4 4区 医学 Q4 PHARMACOLOGY & PHARMACY Acta poloniae pharmaceutica Pub Date : 2022-11-21 DOI:10.32383/appdr/154638
A. Koç, U. Kuyrukluyıldız, Ali Caner Sayar, Mustafa Gazi, B. Süleyman, R. Mammadov, Nergis Akbaş, R. Arslan, H. Suleyman, Bulent Yavuzer
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Abstract

Long-term treatment with tramadol is reported to be toxic to the kidneys. Research shows that tramadol reduces antioxidants and increases oxidants produced in renal tissue. This study aims to investigate the carvacrol effect on tramadol-induced renal injury in rats. The animals were divided into four groups: healthy (HG), individual tramadol (TR), individual carvacrol (CR), and tramadol + carvacrol (TC). Malondialdehyde (MDA), total glutathione (tGSH), glutathione peroxidase (GPO), superoxide dismutase (SOD), total oxidant status (TOS), total antioxidant status (TAS), blood urea nitrogen (BUN), and creatinine (Cr) were measured. Renal tissue was examined histopathologically. MDA, TOS, BUN, and Cr were significantly elevated in group TR and identified as low in group TC compared to group TR but higher than in the HG group. The tGSH, SOD, GPO, and TAS levels were low in group TR and higher in group TC than in group TR but lower than in the HG group. Histological examination of the TR group revealed diffuse necrosis and focal polymorphonuclear leukocytes (PMNLs) in the tubules. In the TC group, tubular atrophy and necrosis were minimal, and PMNL was rare. We observed that tramadol increases oxidants, decreases antioxidants, increases BUN and Cr, and examined whether the toxic effect on renal tissue regressed with carvacrol.
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香芹酚对曲马多诱导的大鼠氧化性肾损伤的影响:生化和组织病理学评价
据报道,长期使用曲马多治疗对肾脏有毒性。研究表明曲马多减少抗氧化剂并增加肾组织中产生的氧化剂。本研究旨在探讨香芹罗对曲马多致大鼠肾损伤的影响。将动物分为健康组(HG)、曲马多单用组(TR)、卡瓦克罗单用组(CR)和曲马多+卡瓦克罗(TC) 4组。测定丙二醛(MDA)、总谷胱甘肽(tGSH)、谷胱甘肽过氧化物酶(GPO)、超氧化物歧化酶(SOD)、总氧化状态(TOS)、总抗氧化状态(TAS)、血尿素氮(BUN)、肌酐(Cr)。肾组织病理检查。MDA、TOS、BUN、Cr在TR组显著升高,TC组较TR组低,但高于HG组。tGSH、SOD、GPO、TAS水平TR组较低,TC组高于TR组,但低于HG组。TR组组织学检查显示小管弥漫性坏死和局灶性多形核白细胞(PMNLs)。TC组小管萎缩和坏死极少,PMNL少见。我们观察到曲马多增加了氧化剂,降低了抗氧化剂,增加了BUN和Cr,并检查了对肾组织的毒性作用是否与香芹酚一起消退。
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
74
审稿时长
6-12 weeks
期刊介绍: The international journal of the Polish Pharmaceutical Society is published in 6 issues a year. The journal offers Open Access publication of original research papers, short communications and reviews written in English, in all areas of pharmaceutical sciences. The following areas of pharmaceutical sciences are covered: Analysis, Biopharmacy, Drug Biochemistry, Drug Synthesis, Natural Drugs, Pharmaceutical Technology, Pharmacology and General. A bimonthly appearing in English since 1994, which continues “Acta Poloniae Pharmaceutica”, whose first issue appeared in December 1937. The war halted the activity of the journal’s creators. Issuance of “Acta Poloniae Pharmaceutica” was resumed in 1947. From 1947 the journal appeared irregularly, initially as a quarterly, then a bimonthly. In the years 1963 – 1973 alongside the Polish version appeared the English edition of the journal. Starting from 1974 only works in English are published in the journal. Since 1995 the journal has been appearing very regularly in two-month intervals (six books a year). The journal publishes original works from all fields of pharmacy, summaries of postdoctoral dissertations and laboratory notes.
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