The Effect of N-butyl-2-Cyanoacrylate on Wound Healing in Head Neck Region

IF 0.2 Q4 OTORHINOLARYNGOLOGY ENT Updates Pub Date : 2019-03-19 DOI:10.32448/ENTUPDATES.425951
Z. Gencer, M. Özkırış, L. Saydam, Y. K. Daglioglu, Oner Sakallioglu, M. Gencer, Y. Koyuncu, S. Polat, A. Kanmaz
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Abstract

OBJECTIVE To compare the histological regeneration characteristics of open wound on head neck by a topical antiseptic solution (Batticon ® solution 5%; Adeka, Samsun, Turkey ) or a tissue adhesive (N-butyl-2-cyanoacrylate, Glubran 2, GEM Company, Italy) in experimentally created rabbit auricular open wound. MATERIAL AND METHOD Twenty-eight female rabbits (New Zealand genus), weighing 3 to 4 kg, were handled daily for 2 weeks prior to surgical manipulation to condition them to behavior testing. The control group consisted of seven rabbits. The 21 rabbits were randomly divided into three groups based on the harvesting day. In control group a segment of ear auricula was resected and sent to histological examination for comparison with the study group findings. In the study group both auricular skin of each animal was exposed and 1x1 cm epidermal resection area was created open wound in rabbit ears that is to be a model for open tissue injury and applied as a topical antiseptic solution (Batticon ® solution 5%; Adeka, Samsun, Turkey) on one side and by application of tissue adhesive (Glubran 2, GEM Company, Italy) on the other side. Following this application at 2 nd , 4 th and 6th days the animals were harvested and histological regeneration characteristics of open wound examined by electron microscopy and compared to the control group’s histological findings. RESULTS Electron microscopic examination of open wound at consecutive 2 nd , 4 th and 6 th days revealed increased regeneration findings in tissue adhesive group when compared to a antiseptic solution group. CONCLUSION Based on the findings of this animal study we conclude that N-butyl-2-cyanoacrylate is an appropriate material for open wound on head and neck region.
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2-氰基丙烯酸正丁酯对头颈部创伤愈合的影响
目的比较外用抗菌液(Batticon®5%溶液)对头颈部开放性创面组织再生的影响;Adeka, Samsun,土耳其)或组织粘合剂(n -丁基-2-氰基丙烯酸酯,Glubran 2, GEM公司,意大利)在实验中创造的兔耳穴开放性伤口。材料与方法28只雌性新西兰兔,体重3 ~ 4kg,在手术前每天处理2周,使其适应行为测试。对照组7只。21只家兔按采收日期随机分为3组。对照组切除一段耳廓,行组织学检查,与研究组比较。在研究组中,暴露每只动物的耳廓皮肤,并在兔耳上创造1x1 cm的表皮切除区域,作为开放性组织损伤模型,并作为外用抗菌溶液(Batticon®溶液5%;一面是Adeka, Samsun,土耳其),另一面是应用组织粘合剂(Glubran 2, GEM公司,意大利)。在第2天、第4天和第6天,收集动物,通过电子显微镜检查开放性伤口的组织学再生特征,并与对照组的组织学结果进行比较。结果连续第2、4、6天对开放性创面进行电镜检查,发现组织粘接剂组较消毒液组再生明显增加。结论基于动物实验结果,我们认为n -丁-2-氰基丙烯酸酯是头颈部开放性创面的合适材料。
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来源期刊
ENT Updates
ENT Updates OTORHINOLARYNGOLOGY-
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