{"title":"Chemical synthesis of TMG-chitotriomycin","authors":"Yunqin Zhang , Guozhi Xiao","doi":"10.1080/07328303.2021.2009504","DOIUrl":null,"url":null,"abstract":"<div><p>TMG-chitotriomycin is a recently discovered β-<em>N</em>-acetylglucosaminidase (GlcNAcase) inhibitor, specific for insect and fungal GlcNAcases. Chemical synthesis is a reliable and effective means to solve the attainability issues of TMG-chitotriomycin, which could facilitate in-depth studies of its biological activities. Thus far, four different synthetic routes toward TMG-chitotriomycin have been reported. Herein, we provide a comprehensive review on the chemical synthesis of TMG-chitotriomycin.</p></div>","PeriodicalId":15311,"journal":{"name":"Journal of Carbohydrate Chemistry","volume":"40 7","pages":"Pages 327-338"},"PeriodicalIF":1.2000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Carbohydrate Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S0732830322000167","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
TMG-chitotriomycin is a recently discovered β-N-acetylglucosaminidase (GlcNAcase) inhibitor, specific for insect and fungal GlcNAcases. Chemical synthesis is a reliable and effective means to solve the attainability issues of TMG-chitotriomycin, which could facilitate in-depth studies of its biological activities. Thus far, four different synthetic routes toward TMG-chitotriomycin have been reported. Herein, we provide a comprehensive review on the chemical synthesis of TMG-chitotriomycin.
TMG-chitotriomycin是一种新发现的β- n -乙酰氨基葡萄糖苷酶(GlcNAcase)抑制剂，对昆虫和真菌GlcNAcase具有特异性。化学合成是解决TMG-chitotriomycin可得性问题的可靠有效手段，有利于深入研究其生物活性。到目前为止，已经报道了四种不同的合成tmg -壳三霉素的途径。本文对化学合成tmg -壳三霉素的研究进展进行了综述。
期刊介绍：
The Journal of Carbohydrate Chemistry serves as an international forum for research advances involving the chemistry and biology of carbohydrates. The following aspects are considered to fall within the scope of this journal:
-novel synthetic methods involving carbohydrates, oligosaccharides, and glycoconjugates-
the use of chemical methods to address aspects of glycobiology-
spectroscopic and crystallographic structure studies of carbohydrates-
computational and molecular modeling studies-
physicochemical studies involving carbohydrates and the chemistry and biochemistry of carbohydrate polymers.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
