Essential Oils of Rosmarinus officinalis and Eucalyptus globulus Cultivated in the Mountainous Region of the State of Rio de Janeiro (Brazil): Chemical Profile and Antileishmanial Activity

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Pharmacognosy Research Pub Date : 2023-02-22 DOI:10.5530/pres.15.2.032
R. C. Zauli, T. Santos, Alberto Wisniewski Jr, P. Xander, A. C. Pascoal
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Abstract

The present study aimed to characterize the chemical profile of essential oils of Rosmarinus officinalis (EORo) and Eucalyptus globulus (EOEg) cultivated in the mountainous region of the state of Rio de Janeiro, Brazil, and to verify the leishmanicidal potential, as well as to determine the cytotoxicity in vitro in mammalian cells. EORo had α-Pinene (37.99%), Cineol (21.48%), D-Verbenone (5.78%) and Limonene (3.28%) as major constituents. The EOEg had as major components Cineol (75.52%), Limonene (8.82%) and o-Cymeno (7.81%). The EOEg had a lower IC 50 value of 14.03 ± 2.08 µg/mL, while EORo had an IC 50 value of 31.12 ± 4.6 µg/mL, both during the 24-hr exposure period. In the 48-hr period, the IC 50 value was almost twice as high with rosemary oil, while in eucalyptus oil there was no significant difference when exposed in this period. The selectivity of EOs was demonstrated in murine cells, showing almost 30 times less toxic to the cell than to the parasite. It can be concluded that this is a pioneering study on the potential of these essential oils against the leishmania parasite. Furthermore, the low toxicity effect on the host cell encourages future studies and in vivo applications.
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里约热内卢州(巴西)山区栽培的迷迭香和蓝桉精油:化学成分和抗炎活性
本研究旨在表征巴西巴西里约热内卢州山区种植的迷迭香(Rosmarinus officinalis, EORo)和蓝桉(Eucalyptus globulus, EOEg)精油的化学成分,并验证其杀利什曼尼潜能,同时测定其体外对哺乳动物细胞的细胞毒性。EORo的主要成分为α-蒎烯(37.99%)、桉树油(21.48%)、d -马尾草酮(5.78%)和柠檬烯(3.28%)。其主要成分为桉叶油(75.52%)、柠檬烯(8.82%)和o-Cymeno(7.81%)。在24小时的暴露期间,EOEg的ic50值为14.03±2.08µg/mL, EORo的ic50值为31.12±4.6µg/mL。在48小时内,迷迭香油的ic50值几乎是其两倍,而桉树油在这段时间内没有显著差异。在小鼠细胞中证明了EOs的选择性,显示对细胞的毒性几乎比对寄生虫的毒性低30倍。可以得出结论,这是一项关于这些精油对抗利什曼原虫潜力的开创性研究。此外,对宿主细胞的低毒性作用鼓励未来的研究和体内应用。
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来源期刊
Pharmacognosy Research
Pharmacognosy Research PHARMACOLOGY & PHARMACY-
自引率
14.30%
发文量
61
期刊介绍: Pharmacognosy Research [ISSN: Print -0976-4836, Online - 0974-8490] [http://www.phcogres.com], Quarterly a publication of Phcog.Net is published by Wolters Kluwer - Medknow Publications. It provides peer-reviewed original research articles from the field of Natural Products. The journal serves an international audience of scientists and researchers in a variety of research and academia by quickly disseminating research findings related to Medicinal Plants and Natural Products. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submissions of original contributions in all areas of pharmacognosy are welcome.
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